PTTG1 and PLCG2

Data Source:
BioGRID (two hybrid)

		PTTG1	PLCG2
Description		PTTG1 regulator of sister chromatid separation, securin	phospholipase C gamma 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Cytosol Plasma Membrane Extracellular Exosome
	Molecular Function	Cysteine-type Endopeptidase Inhibitor Activity Protein Binding SH3 Domain Binding	Phosphotyrosine Residue Binding Phosphatidylinositol Phospholipase C Activity Phospholipase C Activity Protein Binding Phosphorylation-dependent Protein Binding
	Biological Process	DNA Repair Ubiquitin-dependent Protein Catabolic Process Spermatogenesis Negative Regulation Of Endopeptidase Activity Anaphase-promoting Complex-dependent Catabolic Process Homologous Chromosome Segregation Chromosome Organization Cell Division Negative Regulation Of Mitotic Sister Chromatid Separation	Positive Regulation Of Receptor Internalization Stimulatory C-type Lectin Receptor Signaling Pathway Follicular B Cell Differentiation Phosphatidylinositol Biosynthetic Process Phospholipid Catabolic Process Positive Regulation Of Epithelial Cell Migration Wnt Signaling Pathway Calcium-mediated Signaling Platelet Activation B Cell Differentiation Activation Of Store-operated Calcium Channel Activity Positive Regulation Of Type I Interferon Production Response To Lipopolysaccharide Inositol Trisphosphate Biosynthetic Process Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Negative Regulation Of Programmed Cell Death Inositol Phosphate Metabolic Process T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Release Of Sequestered Calcium Ion Into Cytosol
Pathways		APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids	GPVI-mediated activation cascade Toll Like Receptor 4 (TLR4) Cascade Synthesis of IP3 and IP4 in the cytosol Generation of second messenger molecules Role of phospholipids in phagocytosis DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization CLEC7A (Dectin-1) signaling CLEC7A (Dectin-1) signaling Dectin-2 family Dectin-2 family Erythropoietin activates Phospholipase C gamma (PLCG) FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases
GWAS		Dermatomyositis or juvenile dermatomyositis ( 26362759) Insulin-related traits ( 22791750) SjÃ¶gren's syndrome ( 24097067) Systemic lupus erythematosus ( 21408207 28714469 19838195) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031)	Alzheimer's disease (late onset) ( 28714976) Blood protein levels ( 30072576) Breast cancer (menopausal hormone therapy interaction) ( 24080446) Ceramide levels (C24:0) ( 32489964) Coronary artery disease ( 29212778 33020668) Dental caries (decayed, missing and filled teeth) ( 31533690) Height ( 28552196) Inflammatory bowel disease ( 28067908) Mean platelet volume ( 32888494 27863252) Metabolite levels ( 23823483) Platelet count ( 32888494) Platelet distribution width ( 32888494 27863252) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Ulcerative colitis ( 28067908) Upper eyelid morphology ( 29921221) Venous thromboembolism ( 31420334 31676865) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		23 interacting genes: ANAPC11 ANAPC2 AURKA CAMK2A CDC20 CDC27 CDC34 CDK1 CRK CUL1 DNAJA1 FZR1 PLCG2 PPP2R2D PPP2R5A PRKN PTTG1IP RPS10 TP53 UBE2C UBE2N UBE4A XRCC6	56 interacting genes: AR ASB9 BLK BLNK BTK CBLB CD19 DAPP1 EGFR ELK1 EPOR EPYC ERBB2 ERBB3 ERBB4 ESD FCER1G FLT1 FYN GAB1 GAB2 GABPB2 HCK HSPD1 IRS1 ISL1 ITK JAK1 JAK2 KCTD17 KDR KHDRBS1 KIT LAT LAT2 LCK LCP2 LHX8 LIME1 LYN MET NPM1 PRKD1 PTPN6 PTTG1 RALBP1 RTL10 SETD9 SH3BP2 SHC1 SYK TEC TP53 TWIST2 ZKSCAN7 ZNF512B
Entrez ID		9232	5336
HPRD ID		04998	02570
Ensembl ID		ENSG00000164611	ENSG00000197943
Uniprot IDs		O95997 Q6IAL9	P16885
PDB IDs			2K2J 2W2W 2W2X
Enriched GO Terms of Interacting Partners?
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