PTTG1 and ANAPC2

Data Source:
BioGRID (pull down)

		PTTG1	ANAPC2
Description		PTTG1 regulator of sister chromatid separation, securin	anaphase promoting complex subunit 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleoplasm Anaphase-promoting Complex Cytosol
	Molecular Function	Cysteine-type Endopeptidase Inhibitor Activity Protein Binding SH3 Domain Binding	Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	DNA Repair Ubiquitin-dependent Protein Catabolic Process Spermatogenesis Negative Regulation Of Endopeptidase Activity Anaphase-promoting Complex-dependent Catabolic Process Homologous Chromosome Segregation Chromosome Organization Cell Division Negative Regulation Of Mitotic Sister Chromatid Separation	Ubiquitin-dependent Protein Catabolic Process Cell Cycle Negative Regulation Of Gene Expression Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Synaptic Plasticity Positive Regulation Of Axon Extension Positive Regulation Of Dendrite Morphogenesis Cell Division Protein K11-linked Ubiquitination Positive Regulation Of Synapse Maturation Regulation Of Mitotic Cell Cycle Phase Transition
Pathways		APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids	Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Dermatomyositis or juvenile dermatomyositis ( 26362759) Insulin-related traits ( 22791750) SjÃ¶gren's syndrome ( 24097067) Systemic lupus erythematosus ( 21408207 28714469 19838195) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031)	Eosinophil percentage of white cells ( 32888494)
Interacting Genes		23 interacting genes: ANAPC11 ANAPC2 AURKA CAMK2A CDC20 CDC27 CDC34 CDK1 CRK CUL1 DNAJA1 FZR1 PLCG2 PPP2R2D PPP2R5A PRKN PTTG1IP RPS10 TP53 UBE2C UBE2N UBE4A XRCC6	18 interacting genes: ANAPC11 ANAPC7 CDC20 CDC26 CDC27 FBXO5 FZR1 MAD2L1 MEOX1 PTTG1 SMAD2 SUMO2 UBC UBE2C UBE2D2 UBE2S UFD1 WDR5
Entrez ID		9232	29882
HPRD ID		04998	07367
Ensembl ID		ENSG00000164611	ENSG00000176248
Uniprot IDs		O95997 Q6IAL9	Q9UJX6
PDB IDs			4UI9 4YII 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6NXK 6OB1 6Q6G 6Q6H 6TLJ 6TM5
Enriched GO Terms of Interacting Partners?
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