UBE4A and GZMB

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro)

		UBE4A	GZMB
Description		ubiquitination factor E4A	granzyme B
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm	Immunological Synapse Extracellular Region Nucleus Cytoplasm Mitochondrion Cytosol Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Ubiquitin-ubiquitin Ligase Activity	Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent ERAD Pathway	Apoptotic Process Negative Regulation Of Translation Cytolysis Natural Killer Cell Mediated Cytotoxicity Proteolysis Involved In Cellular Protein Catabolic Process Pyroptosis Granzyme-mediated Programmed Cell Death Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	NOTCH2 intracellular domain regulates transcription Activation, myristolyation of BID and translocation to mitochondria
Drugs
Diseases
GWAS		Celiac disease and Rheumatoid arthritis ( 26546613) Fat distribution (HIV) ( 21897333)	Blood protein levels ( 30072576 29875488) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Vitiligo ( 20410501 27723757)
Interacting Genes		13 interacting genes: CASP6 EPHA2 GZMB IP6K1 MAVS PTTG1 RSAD2 SLA UBE2D1 UBE2D2 UBE2D3 UBE2D4 VCP	26 interacting genes: BID CASP3 CASP7 CASP8 CASP9 CD2AP CHRM3 DFFA GRIA3 IGF2R LMNA LMNB1 PARP1 PRF1 PRKDC PTGES3 PTK2 RAB27A SERPINB9 SRGN TUBA1A UBE4A UBE4B XRCC4 XRCC5 XRCC6
Entrez ID		9354	3002
HPRD ID		06793	00476
Ensembl ID		ENSG00000110344	ENSG00000100453
Uniprot IDs		Q14139	J3KQ52 P10144 Q67BC3 Q6XGZ4
PDB IDs		1WGM	1FQ3 1IAU
Enriched GO Terms of Interacting Partners?
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