UBE4A and MAVS

Data Source:
BioGRID (pull down)

		UBE4A	MAVS
Description		ubiquitination factor E4A	mitochondrial antiviral signaling protein
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm	Mitochondrion Mitochondrial Outer Membrane Peroxisomal Membrane Integral Component Of Membrane Mitochondrial Membrane
	Molecular Function	Protein Binding Ubiquitin-ubiquitin Ligase Activity	Protein Binding Protein Kinase Binding Signaling Adaptor Activity CARD Domain Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent ERAD Pathway	Positive Regulation Of Protein Phosphorylation Activation Of Innate Immune Response Positive Regulation Of Defense Response To Virus By Host Positive Regulation Of Myeloid Dendritic Cell Cytokine Production Signal Transduction Viral Process Negative Regulation Of Type I Interferon Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Protein Import Into Nucleus Defense Response To Bacterium Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Viral Genome Replication Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Defense Response To Virus Positive Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Response To Cytokine Stimulus Cellular Response To Exogenous DsRNA Positive Regulation Of Chemokine (C-C Motif) Ligand 5 Production Positive Regulation Of IP-10 Production Regulation Of Peroxisome Organization
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	DDX58/IFIH1-mediated induction of interferon-alpha/beta Ovarian tumor domain proteases TRAF3-dependent IRF activation pathway TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Negative regulators of DDX58/IFIH1 signaling Negative regulators of DDX58/IFIH1 signaling
Drugs
Diseases
GWAS		Celiac disease and Rheumatoid arthritis ( 26546613) Fat distribution (HIV) ( 21897333)	Platelet distribution width ( 32888494)
Interacting Genes		13 interacting genes: CASP6 EPHA2 GZMB IP6K1 MAVS PTTG1 RSAD2 SLA UBE2D1 UBE2D2 UBE2D3 UBE2D4 VCP	20 interacting genes: ABL1 DDX3X DDX58 IKBKB IRF3 IRF5 IRF7 KCNIP3 MAP3K7 OAS3 OTUD4 RIPK2 RNF34 RNF5 SMURF2 STAT1 TBK1 TICAM1 TRAF6 UBE4A
Entrez ID		9354	57506
HPRD ID		06793	13847
Ensembl ID		ENSG00000110344	ENSG00000088888
Uniprot IDs		Q14139	Q7Z434
PDB IDs		1WGM	2MS7 2MS8 2VGQ 3J6C 3J6J 3RC5 4P4H 4Z8M 5JEK
Enriched GO Terms of Interacting Partners?
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