PTTG1 and PPP2R2D

Data Source:
BioGRID (enzymatic study)

		PTTG1	PPP2R2D
Description		PTTG1 regulator of sister chromatid separation, securin	protein phosphatase 2 regulatory subunit Bdelta
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Protein Phosphatase Type 2A Complex Cytosol
	Molecular Function	Cysteine-type Endopeptidase Inhibitor Activity Protein Binding SH3 Domain Binding	Protein Binding Protein Phosphatase Regulator Activity
	Biological Process	DNA Repair Ubiquitin-dependent Protein Catabolic Process Spermatogenesis Negative Regulation Of Endopeptidase Activity Anaphase-promoting Complex-dependent Catabolic Process Homologous Chromosome Segregation Chromosome Organization Cell Division Negative Regulation Of Mitotic Sister Chromatid Separation	Mitotic Cell Cycle Exit From Mitosis Regulation Of Phosphoprotein Phosphatase Activity Cell Division Peptidyl-serine Dephosphorylation
Pathways		APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids	MASTL Facilitates Mitotic Progression
Drugs
Diseases
GWAS		Dermatomyositis or juvenile dermatomyositis ( 26362759) Insulin-related traits ( 22791750) SjÃ¶gren's syndrome ( 24097067) Systemic lupus erythematosus ( 21408207 28714469 19838195) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031)	Amyotrophic lateral sclerosis in C9orf72 mutation positive individuals ( 22959728) Chronotype ( 30696823) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Metabolite levels ( 23823483) Rosacea symptom severity ( 29771307) Systolic blood pressure ( 30224653 30578418)
Interacting Genes		23 interacting genes: ANAPC11 ANAPC2 AURKA CAMK2A CDC20 CDC27 CDC34 CDK1 CRK CUL1 DNAJA1 FZR1 PLCG2 PPP2R2D PPP2R5A PRKN PTTG1IP RPS10 TP53 UBE2C UBE2N UBE4A XRCC6	3 interacting genes: DAPK1 PTTG1 SUPT5H
Entrez ID		9232	55844
HPRD ID		04998	15172
Ensembl ID		ENSG00000164611	ENSG00000175470
Uniprot IDs		O95997 Q6IAL9	Q66LE6 Q6IN90
PDB IDs
Enriched GO Terms of Interacting Partners?
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