PRPF4B and SRSF1

Data Source:
HPRD (in vitro)

		PRPF4B	SRSF1
Description		pre-mRNA processing factor 4B	serine and arginine rich splicing factor 1
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GO Annotations	Cellular Component	Nucleus Chromosome Nuclear Speck Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Exon-exon Junction Complex Catalytic Step 2 Spliceosome
	Molecular Function	RNA Binding Protein Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	RNA Binding MRNA Binding Protein Binding DNA Topoisomerase Binding
	Biological Process	MRNA Splicing, Via Spliceosome Protein Phosphorylation RNA Splicing MRNA Cis Splicing, Via Spliceosome	Alternative MRNA Splicing, Via Spliceosome MRNA 5'-splice Site Recognition MRNA Splicing, Via Spliceosome MRNA Splice Site Selection MRNA Processing RNA Export From Nucleus MRNA Export From Nucleus MRNA 3'-end Processing
Pathways			Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs		Fostamatinib	Copper
Diseases
GWAS		Night sleep phenotypes ( 27126917)	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)
Interacting Genes		8 interacting genes: CLK1 HSPB3 KLF13 PNN POLR3F SRPK2 SRSF1 YWHAG	43 interacting genes: AKAP17A APP BCL10 C1QBP CACNA1A CD8A CDC42 CDK12 CDK6 CLK1 DIDO1 DYRK1A GEMIN2 HIPK3 HNRNPA0 LNX1 LUC7L3 NFYA NXF1 PPARG PRPF4 PRPF4B PSIP1 RNPS1 SCAF11 SNRNP70 SREK1 SRPK1 SRPK2 SRSF10 SRSF11 SRSF4 SRSF5 TCERG1 TNPO3 TOP1 TP53 TRA2B U2AF1 U2AF2 XBP1 YTHDC1 ZRSR2
Entrez ID		8899	6426
HPRD ID		09087	02887
Ensembl ID		ENSG00000112739	ENSG00000136450
Uniprot IDs		A0A024QZY5 Q13523	Q07955 Q59FA2
PDB IDs		4IAN 4IFC 4IIR 4IJP 6CNH 6PJJ 6PK6 6QX9	1X4A 2M7S 2M8D 2O3D 3BEG 4C0O
Enriched GO Terms of Interacting Partners?
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