SRSF1 and PRPF4

Data Source:
HPRD (in vitro)

		SRSF1	PRPF4
Description		serine and arginine rich splicing factor 1	pre-mRNA processing factor 4
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Exon-exon Junction Complex Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Spliceosomal Complex Cajal Body Nuclear Speck U4/U6 X U5 Tri-snRNP Complex U4/U6 SnRNP U2-type Precatalytic Spliceosome Spliceosomal SnRNP Complex
	Molecular Function	RNA Binding MRNA Binding Protein Binding DNA Topoisomerase Binding	Protein Binding U6 SnRNA Binding U4 SnRNA Binding
	Biological Process	Alternative MRNA Splicing, Via Spliceosome MRNA 5'-splice Site Recognition MRNA Splicing, Via Spliceosome MRNA Splice Site Selection MRNA Processing RNA Export From Nucleus MRNA Export From Nucleus MRNA 3'-end Processing	RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome RNA Processing RNA Splicing
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination	mRNA Splicing - Major Pathway
Drugs		Copper
Diseases
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)	White matter growth ( 29682794)
Interacting Genes		43 interacting genes: AKAP17A APP BCL10 C1QBP CACNA1A CD8A CDC42 CDK12 CDK6 CLK1 DIDO1 DYRK1A GEMIN2 HIPK3 HNRNPA0 LNX1 LUC7L3 NFYA NXF1 PPARG PRPF4 PRPF4B PSIP1 RNPS1 SCAF11 SNRNP70 SREK1 SRPK1 SRPK2 SRSF10 SRSF11 SRSF4 SRSF5 TCERG1 TNPO3 TOP1 TP53 TRA2B U2AF1 U2AF2 XBP1 YTHDC1 ZRSR2	9 interacting genes: APP ATP5MF CLK1 GPKOW PPIH SRSF1 TGFBR1 U2AF1 WBP4
Entrez ID		6426	9128
HPRD ID		02887	08479
Ensembl ID		ENSG00000136450	ENSG00000136875
Uniprot IDs		Q07955 Q59FA2	O43172 Q5T1M7
PDB IDs		1X4A 2M7S 2M8D 2O3D 3BEG 4C0O	1MZW 3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9
Enriched GO Terms of Interacting Partners?
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