SRSF1 and ZRSR2

Data Source:
HPRD (two hybrid, in vitro)

		SRSF1	ZRSR2
Description		serine and arginine rich splicing factor 1	zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Exon-exon Junction Complex Catalytic Step 2 Spliceosome	Nucleoplasm Spliceosomal Complex U12-type Spliceosomal Complex U2AF Complex
	Molecular Function	RNA Binding MRNA Binding Protein Binding DNA Topoisomerase Binding	Protein Binding Pre-mRNA 3'-splice Site Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Alternative MRNA Splicing, Via Spliceosome MRNA 5'-splice Site Recognition MRNA Splicing, Via Spliceosome MRNA Splice Site Selection MRNA Processing RNA Export From Nucleus MRNA Export From Nucleus MRNA 3'-end Processing	Spliceosomal Complex Assembly MRNA Splicing, Via Spliceosome RNA Splicing
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination	mRNA Splicing - Minor Pathway
Drugs		Copper
Diseases
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)
Interacting Genes		43 interacting genes: AKAP17A APP BCL10 C1QBP CACNA1A CD8A CDC42 CDK12 CDK6 CLK1 DIDO1 DYRK1A GEMIN2 HIPK3 HNRNPA0 LNX1 LUC7L3 NFYA NXF1 PPARG PRPF4 PRPF4B PSIP1 RNPS1 SCAF11 SNRNP70 SREK1 SRPK1 SRPK2 SRSF10 SRSF11 SRSF4 SRSF5 TCERG1 TNPO3 TOP1 TP53 TRA2B U2AF1 U2AF2 XBP1 YTHDC1 ZRSR2	19 interacting genes: APP CCNL1 CLK2 DVL3 KHDC4 LUC7L2 REP15 SDCBP2 SRPK2 SRRM4 SRSF1 SRSF2 SRSF5 SSX2IP TEPSIN TNFAIP8L1 U2AF1 U2AF2 ZRSR2P1
Entrez ID		6426	8233
HPRD ID		02887	02068
Ensembl ID		ENSG00000136450	ENSG00000169249
Uniprot IDs		Q07955 Q59FA2	Q15696
PDB IDs		1X4A 2M7S 2M8D 2O3D 3BEG 4C0O
Enriched GO Terms of Interacting Partners?
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