SRSF1 and SNRNP70

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		SRSF1	SNRNP70
Description		serine and arginine rich splicing factor 1	small nuclear ribonucleoprotein U1 subunit 70
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Exon-exon Junction Complex Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Spliceosomal Complex U1 SnRNP Nuclear Speck U2-type Prespliceosome
	Molecular Function	RNA Binding MRNA Binding Protein Binding DNA Topoisomerase Binding	RNA Binding MRNA Binding Protein Binding SnRNA Binding U1 SnRNA Binding
	Biological Process	Alternative MRNA Splicing, Via Spliceosome MRNA 5'-splice Site Recognition MRNA Splicing, Via Spliceosome MRNA Splice Site Selection MRNA Processing RNA Export From Nucleus MRNA Export From Nucleus MRNA 3'-end Processing	MRNA Splicing, Via Spliceosome Regulation Of ATPase Activity Regulation Of RNA Splicing Positive Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Protein Refolding Negative Regulation Of Chaperone-mediated Autophagy
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination	mRNA Splicing - Major Pathway
Drugs		Copper
Diseases
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)	Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Systolic blood pressure ( 30224653)
Interacting Genes		43 interacting genes: AKAP17A APP BCL10 C1QBP CACNA1A CD8A CDC42 CDK12 CDK6 CLK1 DIDO1 DYRK1A GEMIN2 HIPK3 HNRNPA0 LNX1 LUC7L3 NFYA NXF1 PPARG PRPF4 PRPF4B PSIP1 RNPS1 SCAF11 SNRNP70 SREK1 SRPK1 SRPK2 SRSF10 SRSF11 SRSF4 SRSF5 TCERG1 TNPO3 TOP1 TP53 TRA2B U2AF1 U2AF2 XBP1 YTHDC1 ZRSR2	46 interacting genes: APP ARSF CASP3 CDC42 CDKL3 CEP63 CHERP CLK2 CRP CTDP1 DDX17 GEMIN2 GTPBP2 HNRNPA2B1 HTATSF1 IL32 IL7R LRP1 MYC NUDT21 PRKD2 PRMT5 PRPF40A RASGRF1 RELA RNF11 SCAF11 SHBG SKIL SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD9 SMURF2 SNRPC SRPK1 SRPK2 SRRM4 SRSF1 SRSF10 SRSF2 TOP1 WBP4 ZRANB2
Entrez ID		6426	6625
HPRD ID		02887	01617
Ensembl ID		ENSG00000136450	ENSG00000104852
Uniprot IDs		Q07955 Q59FA2	A0A024QZD5 P08621 Q9UFS1
PDB IDs		1X4A 2M7S 2M8D 2O3D 3BEG 4C0O	2L5I 2L5J 3CW1 3PGW 4PJO 4PKD 6QX9
Enriched GO Terms of Interacting Partners?
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