PDLIM4 and PTPN13

Data Source:
BioGRID (two hybrid, pull down, enzymatic study, affinity chromatography technology)
HPRD (two hybrid, in vitro)

		PDLIM4	PTPN13
Description		PDZ and LIM domain 4	protein tyrosine phosphatase non-receptor type 13
Image
GO Annotations	Cellular Component	Stress Fiber Nucleus Cytoplasm Cytoskeleton Adherens Junction Z Disc Lamellipodium Early Endosome Membrane Early Endosome Lumen Filamentous Actin Recycling Endosome Lumen Dendritic Spine Postsynaptic Membrane Perinuclear Region Of Cytoplasm Recycling Endosome Membrane	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Lamellipodium Neuron Projection Cell Body Extracellular Exosome
	Molecular Function	Actin Binding Protein Binding Protein Phosphatase Binding Protein Homodimerization Activity Metal Ion Binding Muscle Alpha-actinin Binding Alpha-actinin Binding	Protein Tyrosine Phosphatase Activity Protein Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding
	Biological Process	Heart Development Actin Cytoskeleton Organization Actin Cytoskeleton Reorganization Muscle Structure Development Excitatory Chemical Synaptic Transmission	Negative Regulation Of Protein Phosphorylation Protein Dephosphorylation Phosphatidylinositol Biosynthetic Process Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Dephosphorylation Cellular Response To Cytokine Stimulus
Pathways			Synthesis of PIPs at the plasma membrane Interleukin-37 signaling
Drugs
Diseases
GWAS		Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908 22412388) Height ( 28552196) Inflammatory bowel disease ( 28067908 23128233) Mosquito bite size ( 28199695) Serum metabolite levels ( 23093944) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908)	Eyebrow thickness ( 26926045) Hemoglobin levels ( 32327693) Kidney disease (end stage renal disease vs non-end stage renal disease) in type 1 diabetes ( 27647854) Kidney disease (end stage renal disease vs normoalbuminuria) in type 1 diabetes ( 27647854) Word spelling ( 30741946)
Interacting Genes		8 interacting genes: ABCA1 AMT FAM222B PTPN13 RBPMS SDCBP TRIP6 ZNF408	24 interacting genes: APC ARHGAP29 BEX3 BRD7 CRHR1 CRIP2 CTNNB1 EFNB1 EFNB2 FADD FAS FASLG GHR MTNR1A NFKBIA NGFR PDLIM4 PKN2 PLEKHA1 PLEKHA2 PRKACA RAPGEF6 TRIP6 YWHAZ
Entrez ID		8572	5783
HPRD ID		04571	02602
Ensembl ID		ENSG00000131435	ENSG00000163629
Uniprot IDs		A0A0S2Z4N4 P50479	Q12923
PDB IDs		2EEG 2V1W 4Q2O	1D5G 1Q7X 1WCH 2M0Z 2M10 3LNX 3LNY 3PDZ 5GLJ
Enriched GO Terms of Interacting Partners?
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