PTPN13 and RAPGEF6

Data Source:
HPRD (in vitro, two hybrid)

		PTPN13	RAPGEF6
Description		protein tyrosine phosphatase non-receptor type 13	Rap guanine nucleotide exchange factor 6
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GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Lamellipodium Neuron Projection Cell Body Extracellular Exosome	Centrosome Cytosol Plasma Membrane Apical Plasma Membrane Endocytic Vesicle
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding	Guanyl-nucleotide Exchange Factor Activity Protein Binding GTP-dependent Protein Binding Small GTPase Binding Phosphatidic Acid Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Protein Dephosphorylation Phosphatidylinositol Biosynthetic Process Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Dephosphorylation Cellular Response To Cytokine Stimulus	Ras Protein Signal Transduction Microvillus Assembly Regulation Of GTPase Activity Positive Regulation Of GTPase Activity Protein Localization To Plasma Membrane Establishment Of Endothelial Intestinal Barrier
Pathways		Synthesis of PIPs at the plasma membrane Interleukin-37 signaling
Drugs
Diseases
GWAS		Eyebrow thickness ( 26926045) Hemoglobin levels ( 32327693) Kidney disease (end stage renal disease vs non-end stage renal disease) in type 1 diabetes ( 27647854) Kidney disease (end stage renal disease vs normoalbuminuria) in type 1 diabetes ( 27647854) Word spelling ( 30741946)	Alzheimer's disease in APOE e4- carriers ( 25778476) Asthma ( 32296059) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Diisocyanate-induced asthma ( 25918132) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mosquito bite size ( 28199695) Perceived unattractiveness to mosquitoes ( 28199695) Subcortical volume (MOSTest) ( 32665545) Subjective well-being ( 27089181) Ulcerative colitis ( 28067908)
Interacting Genes		24 interacting genes: APC ARHGAP29 BEX3 BRD7 CRHR1 CRIP2 CTNNB1 EFNB1 EFNB2 FADD FAS FASLG GHR MTNR1A NFKBIA NGFR PDLIM4 PKN2 PLEKHA1 PLEKHA2 PRKACA RAPGEF6 TRIP6 YWHAZ	8 interacting genes: ABCA1 LINC00839 MRAS NEDD4 PTPN13 RAP1A RAP2A YWHAG
Entrez ID		5783	51735
HPRD ID		02602	11483
Ensembl ID		ENSG00000163629	ENSG00000158987
Uniprot IDs		Q12923	B2RTU6 Q8TEU7
PDB IDs		1D5G 1Q7X 1WCH 2M0Z 2M10 3LNX 3LNY 3PDZ 5GLJ	2D93 3LNY
Enriched GO Terms of Interacting Partners?
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