PTPN13 and EFNB1

Data Source:
HPRD (in vitro, in vivo)

		PTPN13	EFNB1
Description		protein tyrosine phosphatase non-receptor type 13	ephrin B1
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GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Lamellipodium Neuron Projection Cell Body Extracellular Exosome	Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Membrane Raft Synapse Extracellular Exosome
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding	Protein Binding Ephrin Receptor Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Protein Dephosphorylation Phosphatidylinositol Biosynthetic Process Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Dephosphorylation Cellular Response To Cytokine Stimulus	Neural Crest Cell Migration Cell Adhesion Cell-cell Signaling Axon Guidance Embryonic Pattern Specification T Cell Costimulation Positive Regulation Of T Cell Proliferation Ephrin Receptor Signaling Pathway
Pathways		Synthesis of PIPs at the plasma membrane Interleukin-37 signaling	EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells
Drugs
Diseases			Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome
GWAS		Eyebrow thickness ( 26926045) Hemoglobin levels ( 32327693) Kidney disease (end stage renal disease vs non-end stage renal disease) in type 1 diabetes ( 27647854) Kidney disease (end stage renal disease vs normoalbuminuria) in type 1 diabetes ( 27647854) Word spelling ( 30741946)
Interacting Genes		24 interacting genes: APC ARHGAP29 BEX3 BRD7 CRHR1 CRIP2 CTNNB1 EFNB1 EFNB2 FADD FAS FASLG GHR MTNR1A NFKBIA NGFR PDLIM4 PKN2 PLEKHA1 PLEKHA2 PRKACA RAPGEF6 TRIP6 YWHAZ	18 interacting genes: ANKRD46 CAPN10 CUL3 DNAJC5 EPHA3 EPHB1 EPHB2 GRIP1 MYC NCK2 PICK1 PTPN13 RGS3 SDCBP SORBS1 SRC TIAM1 YWHAQ
Entrez ID		5783	1947
HPRD ID		02602	02072
Ensembl ID		ENSG00000163629	ENSG00000090776
Uniprot IDs		Q12923	P98172
PDB IDs		1D5G 1Q7X 1WCH 2M0Z 2M10 3LNX 3LNY 3PDZ 5GLJ	6THG
Enriched GO Terms of Interacting Partners?
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