PTPN13 and NFKBIA

Data Source:
BioGRID (pull down)
HPRD (in vitro, two hybrid, in vivo)

		PTPN13	NFKBIA
Description		protein tyrosine phosphatase non-receptor type 13	NFKB inhibitor alpha
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GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Lamellipodium Neuron Projection Cell Body Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane I-kappaB/NF-kappaB Complex
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding	Protein Binding Transcription Factor Binding Nuclear Localization Sequence Binding Enzyme Binding Ubiquitin Protein Ligase Binding Identical Protein Binding NF-kappaB Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Protein Dephosphorylation Phosphatidylinositol Biosynthetic Process Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Dephosphorylation Cellular Response To Cytokine Stimulus	Protein Import Into Nucleus Apoptotic Process I-kappaB Kinase/NF-kappaB Signaling Cytoplasmic Sequestering Of NF-kappaB Negative Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Efflux Negative Regulation Of Lipid Storage Viral Process Protein Deubiquitination Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Cellular Protein Metabolic Process Response To Muramyl Dipeptide Tumor Necrosis Factor-mediated Signaling Pathway Toll-like Receptor 4 Signaling Pathway Response To Muscle Stretch Regulation Of Cell Population Proliferation Cytoplasmic Sequestering Of Transcription Factor Negative Regulation Of Apoptotic Process Response To Exogenous DsRNA Negative Regulation Of DNA Binding Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Inflammatory Response Cellular Response To Cold Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Interleukin-1-mediated Signaling Pathway Regulation Of NIK/NF-kappaB Signaling
Pathways		Synthesis of PIPs at the plasma membrane Interleukin-37 signaling	Activation of NF-kappaB in B cells RIP-mediated NFkB activation via ZBP1 Downstream TCR signaling NF-kB is activated and signals survival FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex SUMOylation of immune response proteins IkBA variant leads to EDA-ID CLEC7A (Dectin-1) signaling Ub-specific processing proteases Interleukin-1 signaling TRAF6 mediated NF-kB activation
Drugs			Acetylsalicylic acid Bardoxolone methyl Astaxanthin
Diseases			Ectodermal dysplasia associated immunodeficiency (EDA-ID), including the following two diseases: NF-kappa-B essential modulator (NEMO) defect; Inhibitor of kappa-B (I-kappa-B) defect Hodgkin lymphoma
GWAS		Eyebrow thickness ( 26926045) Hemoglobin levels ( 32327693) Kidney disease (end stage renal disease vs non-end stage renal disease) in type 1 diabetes ( 27647854) Kidney disease (end stage renal disease vs normoalbuminuria) in type 1 diabetes ( 27647854) Word spelling ( 30741946)	Asthma ( 30929738 32296059) Asthma (childhood onset) ( 30929738) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Creatine kinase levels ( 29403010) Eczema ( 31361310) Hip circumference adjusted for BMI ( 25673412) Inflammatory skin disease ( 25574825) Lymphocyte counts ( 32888494 27863252) Monocyte count ( 32888494) PR interval ( 32439900) Psoriasis ( 25854761 25903422 20953189 20953190 25574825 23143594) Psoriasis vulgaris ( 26626624) Pulse pressure ( 27841878 30578418) Systolic blood pressure ( 27841878 28739976 30578418) White blood cell count ( 32888494)
Interacting Genes		24 interacting genes: APC ARHGAP29 BEX3 BRD7 CRHR1 CRIP2 CTNNB1 EFNB1 EFNB2 FADD FAS FASLG GHR MTNR1A NFKBIA NGFR PDLIM4 PKN2 PLEKHA1 PLEKHA2 PRKACA RAPGEF6 TRIP6 YWHAZ	89 interacting genes: ABL1 ARRB1 ARRB2 ATF4 AURKA BARD1 BTRC CAPN1 CAPN2 CD7 CDC34 CHUK COMMD1 COPS8 CSNK2A1 CUL1 DNAJA3 DYNLL1 EIF2AK2 ELP1 ENKD1 FBXW11 G3BP2 HDAC1 HDAC3 HNRNPA1 HOXA9 HOXB7 HSPB1 IKBKB IKBKE IKBKG IKZF4 ITPK1 JAK2 LCK LYL1 MAP3K1 MAP3K14 MAP3K2 MAP3K3 MAP3K7 MCM5 MCM7 MED19 NCOR2 NEDD9 NFKB1 NFKB2 NFKBIB NKIRAS1 NKIRAS2 PIK3R1 PIR POLR2C POM121 PRKCA PRKCI PSMA2 PSMD3 PTPN1 PTPN13 REL RELA RNF115 RPS6KA1 RPS6KA3 RWDD3 SKP1 SLC25A4 SLC25A5 SRC ST7 SUMO1 SUMO4 TBK1 TCL1A TNF TNFSF11 TP53 TUBA1B UBE2D1 UBE2D2 UBE2D3 UBE2E3 UBE2I UBE2L3 VCP ZNF212
Entrez ID		5783	4792
HPRD ID		02602	01235
Ensembl ID		ENSG00000163629	ENSG00000100906
Uniprot IDs		Q12923	P25963
PDB IDs		1D5G 1Q7X 1WCH 2M0Z 2M10 3LNX 3LNY 3PDZ 5GLJ	1IKN 1NFI 6TTU 6Y1J
Enriched GO Terms of Interacting Partners?
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