PTPN13 and PKN2

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo, two hybrid)

		PTPN13	PKN2
Description		protein tyrosine phosphatase non-receptor type 13	protein kinase N2
Image
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Lamellipodium Neuron Projection Cell Body Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Plasma Membrane Nuclear Body Lamellipodium Midbody Cleavage Furrow Protein-containing Complex Apical Junction Complex Intermediate Filament Cytoskeleton Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding	RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Calcium-dependent Protein Kinase C Activity Protein Binding ATP Binding Kinase Activity Histone Deacetylase Binding Cadherin Binding RNA Polymerase Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Protein Dephosphorylation Phosphatidylinositol Biosynthetic Process Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Dephosphorylation Cellular Response To Cytokine Stimulus	Protein Phosphorylation Apoptotic Process Cell Cycle Cell Adhesion Signal Transduction Epithelial Cell Migration Viral Process Peptidyl-serine Phosphorylation Cell Projection Organization Positive Regulation Of Cytokinesis Intracellular Signal Transduction Apical Junction Assembly Positive Regulation Of Viral Genome Replication Positive Regulation Of Mitotic Cell Cycle Cell Division Regulation Of Cell Motility
Pathways		Synthesis of PIPs at the plasma membrane Interleukin-37 signaling	RHO GTPases activate PKNs
Drugs			Fostamatinib
Diseases
GWAS		Eyebrow thickness ( 26926045) Hemoglobin levels ( 32327693) Kidney disease (end stage renal disease vs non-end stage renal disease) in type 1 diabetes ( 27647854) Kidney disease (end stage renal disease vs normoalbuminuria) in type 1 diabetes ( 27647854) Word spelling ( 30741946)	Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Coronary artery disease ( 29212778) Diastolic blood pressure ( 27841878) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density ( 30598549 28869591) Height ( 20881960 25282103 31562340) Intraocular pressure ( 29617998) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Narcolepsy ( 23459209) Neonatal total 25-hydroxyvitamin D levels (maternal genetic effect) ( 32047095) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Periodontal microbiota ( 22699663) Photic sneeze reflex ( 27182965) Pulse pressure ( 27841878) Red blood cell count ( 32888494) Refractive error ( 32231278) Response to fenofibrate (LDL cholesterol levels) ( 27002377) Rosacea symptom severity ( 29771307) Serum protein levels (sST2) ( 23999434) Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) ( 31557306) Systolic blood pressure ( 30224653 27841878) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		24 interacting genes: APC ARHGAP29 BEX3 BRD7 CRHR1 CRIP2 CTNNB1 EFNB1 EFNB2 FADD FAS FASLG GHR MTNR1A NFKBIA NGFR PDLIM4 PKN2 PLEKHA1 PLEKHA2 PRKACA RAPGEF6 TRIP6 YWHAZ	18 interacting genes: AKT1 CASP3 CCDC136 CHGB EEF1A1 EIF3G FAM193B HDAC5 MAP3K2 MYO9B NCK1 NCK2 NEDD4 PDPK1 PLCG1 PTPN13 RHOA SUMO2
Entrez ID		5783	5586
HPRD ID		02602	03972
Ensembl ID		ENSG00000163629	ENSG00000065243
Uniprot IDs		Q12923	Q16513
PDB IDs		1D5G 1Q7X 1WCH 2M0Z 2M10 3LNX 3LNY 3PDZ 5GLJ	4CRS 4RRV 6CCY 6GBE
Enriched GO Terms of Interacting Partners?
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