PTPN13 and PLEKHA1

Data Source:
BioGRID (affinity chromatography technology, imaging technique)
HPRD (in vitro)

		PTPN13	PLEKHA1
Description		protein tyrosine phosphatase non-receptor type 13	pleckstrin homology domain containing A1
Image
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Lamellipodium Neuron Projection Cell Body Extracellular Exosome	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Ruffle Membrane Extracellular Exosome
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding	Protein Binding Lipid Binding PDZ Domain Binding Phosphatidylinositol-3,4-bisphosphate Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Protein Dephosphorylation Phosphatidylinositol Biosynthetic Process Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Dephosphorylation Cellular Response To Cytokine Stimulus	Luteinization Phosphatidylinositol Biosynthetic Process Spermatogenesis Androgen Metabolic Process Estrogen Metabolic Process Post-embryonic Development Phosphatidylinositol 3-kinase Signaling Ruffle Organization Leydig Cell Differentiation Multicellular Organism Growth Establishment Of Protein Localization Platelet-derived Growth Factor Receptor Signaling Pathway Skeletal System Morphogenesis B Cell Receptor Signaling Pathway Negative Regulation Of Protein Kinase B Signaling Roof Of Mouth Development Face Morphogenesis Cellular Response To Hydrogen Peroxide
Pathways		Synthesis of PIPs at the plasma membrane Interleukin-37 signaling	Synthesis of PIPs at the plasma membrane
Drugs			Citric acid
Diseases
GWAS		Eyebrow thickness ( 26926045) Hemoglobin levels ( 32327693) Kidney disease (end stage renal disease vs non-end stage renal disease) in type 1 diabetes ( 27647854) Kidney disease (end stage renal disease vs normoalbuminuria) in type 1 diabetes ( 27647854) Word spelling ( 30741946)	Age-related macular degeneration ( 23577725 23536807) Age-related macular degeneration (extreme sampling) ( 23577725) Autoimmune thyroid disease ( 32581359) Birth weight ( 31043758 27680694) Central corneal thickness ( 32528159) Femoral neck bone mineral density ( 29499414) Height ( 31562340 20189936) Medication use (thyroid preparations) ( 31015401) Offspring birth weight ( 31043758) Refractive error ( 32231278) Type 1 diabetes in high risk HLA genotype individuals (time to event) ( 29310926) Type 2 diabetes ( 28566273 24509480 30054458 30297969 32499647 30718926 28869590)
Interacting Genes		24 interacting genes: APC ARHGAP29 BEX3 BRD7 CRHR1 CRIP2 CTNNB1 EFNB1 EFNB2 FADD FAS FASLG GHR MTNR1A NFKBIA NGFR PDLIM4 PKN2 PLEKHA1 PLEKHA2 PRKACA RAPGEF6 TRIP6 YWHAZ	8 interacting genes: CLDN14 CRKL FBXO7 MPDZ PLEKHA2 PTPN13 SH3BP4 SNTG1
Entrez ID		5783	59338
HPRD ID		02602	09686
Ensembl ID		ENSG00000163629	ENSG00000107679
Uniprot IDs		Q12923	B3KQL5 Q5RGS4 Q9HB21
PDB IDs		1D5G 1Q7X 1WCH 2M0Z 2M10 3LNX 3LNY 3PDZ 5GLJ	1EAZ
Enriched GO Terms of Interacting Partners?
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