ULK1 and SMCR8

Data Source:
BioGRID (two hybrid)

		ULK1	SMCR8
Description		unc-51 like autophagy activating kinase 1	SMCR8-C9orf72 complex subunit
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GO Annotations	Cellular Component	Cytoplasm Mitochondrial Outer Membrane Autophagosome Endoplasmic Reticulum Membrane Cytosol Axon Guanyl-nucleotide Exchange Factor Complex Phagophore Assembly Site Membrane Recycling Endosome Extrinsic Component Of Omegasome Membrane Extrinsic Component Of Phagophore Assembly Site Membrane Extrinsic Component Of Autophagosome Membrane Atg1/ULK1 Kinase Complex	Chromatin Nucleoplasm Cytoplasm Guanyl-nucleotide Exchange Factor Complex Atg1/ULK1 Kinase Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Small GTPase Binding Identical Protein Binding Protein-containing Complex Binding GTPase Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Protein Kinase Inhibitor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Kinase Binding
	Biological Process	Protein Phosphorylation Autophagy Signal Transduction Protein Localization Positive Regulation Of Autophagy Macroautophagy Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Neuron Projection Regeneration Neuron Projection Development Negative Regulation Of Protein-containing Complex Assembly Cellular Response To Nutrient Levels Response To Starvation Protein Autophosphorylation Axon Extension Positive Regulation By Symbiont Of Host Autophagy Positive Regulation Of Autophagosome Assembly	Negative Regulation Of Protein Kinase Activity Autophagy Regulation Of Autophagy Negative Regulation Of Gene Expression Negative Regulation Of Macroautophagy Positive Regulation Of TOR Signaling Positive Regulation Of Autophagosome Maturation Negative Regulation Of Autophagosome Assembly Regulation Of TORC1 Signaling
Pathways		Macroautophagy TBC/RABGAPs RAB GEFs exchange GTP for GDP on RABs Receptor Mediated Mitophagy
Drugs		Fostamatinib
Diseases
GWAS		Body mass index ( 26426971) Mercury levels ( 26025379)	Change in neurofilament light levels ( 31295725) Diastolic blood pressure ( 30578418) Systolic blood pressure ( 30578418)
Interacting Genes		19 interacting genes: ATG9A BECN1 EXOC8 GABARAP GABARAPL1 GABARAPL2 MAPK14 MBP MEFV MUL1 NEDD4L OCLN PPP1CA PRKAA1 SDCBP SMCR8 SYNGAP1 UBC USP20	4 interacting genes: ATG13 C9orf72 TBK1 ULK1
Entrez ID		8408	140775
HPRD ID		11933	18075
Ensembl ID		ENSG00000177169	ENSG00000176994
Uniprot IDs		O75385	Q8TEV9
PDB IDs		4WNO 4WNP 5CI7 6HYO 6MNH 6QAS	6LT0 6V4U
Enriched GO Terms of Interacting Partners?
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