SMCR8 and ATG13

Data Source:
BioGRID (two hybrid)

		SMCR8	ATG13
Description		SMCR8-C9orf72 complex subunit	autophagy related 13
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GO Annotations	Cellular Component	Chromatin Nucleoplasm Cytoplasm Guanyl-nucleotide Exchange Factor Complex Atg1/ULK1 Kinase Complex	Phagophore Assembly Site Mitochondrion Endoplasmic Reticulum Membrane Cytosol Extrinsic Component Of Membrane Atg1/ULK1 Kinase Complex
	Molecular Function	Protein Kinase Inhibitor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Kinase Binding	Protein Binding Protein Kinase Binding
	Biological Process	Negative Regulation Of Protein Kinase Activity Autophagy Regulation Of Autophagy Negative Regulation Of Gene Expression Negative Regulation Of Macroautophagy Positive Regulation Of TOR Signaling Positive Regulation Of Autophagosome Maturation Negative Regulation Of Autophagosome Assembly Regulation Of TORC1 Signaling	Autophagosome Assembly Mitophagy Macroautophagy Regulation Of Macroautophagy Protein Localization To Phagophore Assembly Site Piecemeal Microautophagy Of The Nucleus Response To Mitochondrial Depolarisation Positive Regulation Of Protein Targeting To Mitochondrion
Pathways			Macroautophagy
Drugs
Diseases
GWAS		Change in neurofilament light levels ( 31295725) Diastolic blood pressure ( 30578418) Systolic blood pressure ( 30578418)	Age at first sexual intercourse ( 27089180) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Headache ( 29397368) Immunoglobulin A ( 20694011) Reaction time ( 29844566) Schizophrenia ( 29483656) Selective IgA deficiency ( 27723758)
Interacting Genes		4 interacting genes: ATG13 C9orf72 TBK1 ULK1	10 interacting genes: APP ATG101 ATG14 GABARAP GABARAPL1 GABARAPL2 MAP1LC3A MAP1LC3B MAP1LC3C SMCR8
Entrez ID		140775	9776
HPRD ID		18075	13809
Ensembl ID		ENSG00000176994	ENSG00000175224
Uniprot IDs		Q8TEV9	A8K0S6 O75143
PDB IDs		6LT0 6V4U	3WAN 3WAO 3WAP 5C50 5XUY 5XV1 5XV3 5XV4 5XV6 6HYN
Enriched GO Terms of Interacting Partners?
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