SMCR8 and ULK1

Data Source:
BioGRID (two hybrid)

		SMCR8	ULK1
Description		SMCR8-C9orf72 complex subunit	unc-51 like autophagy activating kinase 1
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GO Annotations	Cellular Component	Chromatin Nucleoplasm Cytoplasm Guanyl-nucleotide Exchange Factor Complex Atg1/ULK1 Kinase Complex	Cytoplasm Mitochondrial Outer Membrane Autophagosome Endoplasmic Reticulum Membrane Cytosol Axon Guanyl-nucleotide Exchange Factor Complex Phagophore Assembly Site Membrane Recycling Endosome Extrinsic Component Of Omegasome Membrane Extrinsic Component Of Phagophore Assembly Site Membrane Extrinsic Component Of Autophagosome Membrane Atg1/ULK1 Kinase Complex
	Molecular Function	Protein Kinase Inhibitor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Protein Kinase Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Small GTPase Binding Identical Protein Binding Protein-containing Complex Binding GTPase Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Negative Regulation Of Protein Kinase Activity Autophagy Regulation Of Autophagy Negative Regulation Of Gene Expression Negative Regulation Of Macroautophagy Positive Regulation Of TOR Signaling Positive Regulation Of Autophagosome Maturation Negative Regulation Of Autophagosome Assembly Regulation Of TORC1 Signaling	Protein Phosphorylation Autophagy Signal Transduction Protein Localization Positive Regulation Of Autophagy Macroautophagy Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Neuron Projection Regeneration Neuron Projection Development Negative Regulation Of Protein-containing Complex Assembly Cellular Response To Nutrient Levels Response To Starvation Protein Autophosphorylation Axon Extension Positive Regulation By Symbiont Of Host Autophagy Positive Regulation Of Autophagosome Assembly
Pathways			Macroautophagy TBC/RABGAPs RAB GEFs exchange GTP for GDP on RABs Receptor Mediated Mitophagy
Drugs			Fostamatinib
Diseases
GWAS		Change in neurofilament light levels ( 31295725) Diastolic blood pressure ( 30578418) Systolic blood pressure ( 30578418)	Body mass index ( 26426971) Mercury levels ( 26025379)
Interacting Genes		4 interacting genes: ATG13 C9orf72 TBK1 ULK1	19 interacting genes: ATG9A BECN1 EXOC8 GABARAP GABARAPL1 GABARAPL2 MAPK14 MBP MEFV MUL1 NEDD4L OCLN PPP1CA PRKAA1 SDCBP SMCR8 SYNGAP1 UBC USP20
Entrez ID		140775	8408
HPRD ID		18075	11933
Ensembl ID		ENSG00000176994	ENSG00000177169
Uniprot IDs		Q8TEV9	O75385
PDB IDs		6LT0 6V4U	4WNO 4WNP 5CI7 6HYO 6MNH 6QAS
Enriched GO Terms of Interacting Partners?
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