CASP6 and UBE4A

Data Source:
BioGRID (enzymatic study)

		CASP6	UBE4A
Description		caspase 6	ubiquitination factor E4A
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Ubiquitin Ligase Complex Nucleus Cytoplasm
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Peptidase Activity Identical Protein Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis	Protein Binding Ubiquitin-ubiquitin Ligase Activity
	Biological Process	Proteolysis Apoptotic Process Epithelial Cell Differentiation Regulation Of Apoptotic Process Cellular Response To Staurosporine Execution Phase Of Apoptosis	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Ubiquitin-dependent ERAD Pathway
Pathways		Apoptotic cleavage of cellular proteins Caspase-mediated cleavage of cytoskeletal proteins Breakdown of the nuclear lamina TP53 Regulates Transcription of Caspase Activators and Caspases	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Risk-taking tendency (4-domain principal component model) ( 30643258)	Celiac disease and Rheumatoid arthritis ( 26546613) Fat distribution (HIV) ( 21897333)
Interacting Genes		42 interacting genes: APP CASP10 CASP3 CASP8 CFLAR CHD3 COPS6 DSP EIF2S1 HTT IKBKG KRT18 LMNA LMNB1 LNX1 MAPK6 MAPT NEDD4 NTAQ1 NUAK1 PCYT1A PIN1 PKIA PPL PRKAB2 PRKCZ PSEN1 PSEN2 PSME3 RB1 SATB1 SP1 SRF SRP72 STUB1 TAB1 TFAP2A TOP1 TRAF1 UBE4A UBE4B VIM	13 interacting genes: CASP6 EPHA2 GZMB IP6K1 MAVS PTTG1 RSAD2 SLA UBE2D1 UBE2D2 UBE2D3 UBE2D4 VCP
Entrez ID		839	9354
HPRD ID		03321	06793
Ensembl ID		ENSG00000138794	ENSG00000110344
Uniprot IDs		P55212	Q14139
PDB IDs		1MI9 2WDP 3K7E 3NKF 3NR2 3OD5 3P45 3P4U 3QNW 3S70 3S8E 3V6L 3V6M 4EJF 4FXO 4HVA 4IYR 4N5D 4N6G 4N7J 4N7M 4NBK 4NBL 4NBN 6DEU 6DEV	1WGM
Enriched GO Terms of Interacting Partners?
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