CASP6 and PCYT1A

Data Source:
HPRD (in vivo, in vitro)

		CASP6	PCYT1A
Description		caspase 6	phosphate cytidylyltransferase 1, choline, alpha
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Glycogen Granule
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Peptidase Activity Identical Protein Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis	Choline-phosphate Cytidylyltransferase Activity Protein Binding Phosphatidylcholine Binding Identical Protein Binding
	Biological Process	Proteolysis Apoptotic Process Epithelial Cell Differentiation Regulation Of Apoptotic Process Cellular Response To Staurosporine Execution Phase Of Apoptosis	Phosphatidylcholine Biosynthetic Process CDP-choline Pathway
Pathways		Apoptotic cleavage of cellular proteins Caspase-mediated cleavage of cytoskeletal proteins Breakdown of the nuclear lamina TP53 Regulates Transcription of Caspase Activators and Caspases	Synthesis of PC
Drugs			Choline Choline salicylate
Diseases
GWAS		Risk-taking tendency (4-domain principal component model) ( 30643258)	Mean platelet volume ( 32888494)
Interacting Genes		42 interacting genes: APP CASP10 CASP3 CASP8 CFLAR CHD3 COPS6 DSP EIF2S1 HTT IKBKG KRT18 LMNA LMNB1 LNX1 MAPK6 MAPT NEDD4 NTAQ1 NUAK1 PCYT1A PIN1 PKIA PPL PRKAB2 PRKCZ PSEN1 PSEN2 PSME3 RB1 SATB1 SP1 SRF SRP72 STUB1 TAB1 TFAP2A TOP1 TRAF1 UBE4A UBE4B VIM	16 interacting genes: ACTB AGTRAP CASP6 CASP8 FKBP7 GYS1 MAGEA3 MOB1A MOB3C PCYT1B RNF8 SCAMP1 SDCBP SNAPIN TNFRSF10D VKORC1L1
Entrez ID		839	5130
HPRD ID		03321	00438
Ensembl ID		ENSG00000138794	ENSG00000161217
Uniprot IDs		P55212	B4E322 P49585
PDB IDs		1MI9 2WDP 3K7E 3NKF 3NR2 3OD5 3P45 3P4U 3QNW 3S70 3S8E 3V6L 3V6M 4EJF 4FXO 4HVA 4IYR 4N5D 4N6G 4N7J 4N7M 4NBK 4NBL 4NBN 6DEU 6DEV
Enriched GO Terms of Interacting Partners?
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