CASP6 and SRP72

Data Source:
HPRD (in vitro)

		CASP6	SRP72
Description		caspase 6	signal recognition particle 72
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Endoplasmic Reticulum Signal Recognition Particle, Endoplasmic Reticulum Targeting Cytosol Signal Recognition Particle
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Peptidase Activity Identical Protein Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis	RNA Binding Signal Recognition Particle Binding Protein Binding 7S RNA Binding TPR Domain Binding Ribosome Binding
	Biological Process	Proteolysis Apoptotic Process Epithelial Cell Differentiation Regulation Of Apoptotic Process Cellular Response To Staurosporine Execution Phase Of Apoptosis	SRP-dependent Cotranslational Protein Targeting To Membrane
Pathways		Apoptotic cleavage of cellular proteins Caspase-mediated cleavage of cytoskeletal proteins Breakdown of the nuclear lamina TP53 Regulates Transcription of Caspase Activators and Caspases	SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane
Drugs
Diseases
GWAS		Risk-taking tendency (4-domain principal component model) ( 30643258)	Airflow obstruction ( 22837378)
Interacting Genes		42 interacting genes: APP CASP10 CASP3 CASP8 CFLAR CHD3 COPS6 DSP EIF2S1 HTT IKBKG KRT18 LMNA LMNB1 LNX1 MAPK6 MAPT NEDD4 NTAQ1 NUAK1 PCYT1A PIN1 PKIA PPL PRKAB2 PRKCZ PSEN1 PSEN2 PSME3 RB1 SATB1 SP1 SRF SRP72 STUB1 TAB1 TFAP2A TOP1 TRAF1 UBE4A UBE4B VIM	10 interacting genes: CASP3 CASP6 CDC42 FCHSD2 HSPB1 PYGM SKIL SRP68 SULT2B1 TULP3
Entrez ID		839	6731
HPRD ID		03321	03671
Ensembl ID		ENSG00000138794	ENSG00000174780
Uniprot IDs		P55212	O76094 V9HWK0
PDB IDs		1MI9 2WDP 3K7E 3NKF 3NR2 3OD5 3P45 3P4U 3QNW 3S70 3S8E 3V6L 3V6M 4EJF 4FXO 4HVA 4IYR 4N5D 4N6G 4N7J 4N7M 4NBK 4NBL 4NBN 6DEU 6DEV	5M72 5M73 5WRV 5WRW
Enriched GO Terms of Interacting Partners?
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