CASP6 and SATB1

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo, in vitro)

		CASP6	SATB1
Description		caspase 6	SATB homeobox 1
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Chromatin Nucleus Nucleoplasm Nuclear Matrix Nuclear Body PML Body
	Molecular Function	Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Peptidase Activity Identical Protein Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Double-stranded DNA Binding Protein Binding Sequence-specific DNA Binding
	Biological Process	Proteolysis Apoptotic Process Epithelial Cell Differentiation Regulation Of Apoptotic Process Cellular Response To Staurosporine Execution Phase Of Apoptosis	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Viral Process
Pathways		Apoptotic cleavage of cellular proteins Caspase-mediated cleavage of cytoskeletal proteins Breakdown of the nuclear lamina TP53 Regulates Transcription of Caspase Activators and Caspases	Apoptotic cleavage of cellular proteins SUMOylation of chromatin organization proteins
Drugs
Diseases
GWAS		Risk-taking tendency (4-domain principal component model) ( 30643258)	Adventurousness ( 30643258) Chronic mucus hypersecretion ( 24714607) Familial lung adenocarcinoma ( 29924316) General risk tolerance (MTAG) ( 30643258) Itch intensity from mosquito bite ( 28199695) Left-handedness ( 32989287) Parkinson's disease ( 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Platelet count ( 22139419) Response to fenofibrate (HDL cholesterol levels) ( 27002377) SjÃ¶gren's syndrome ( 24097067)
Interacting Genes		42 interacting genes: APP CASP10 CASP3 CASP8 CFLAR CHD3 COPS6 DSP EIF2S1 HTT IKBKG KRT18 LMNA LMNB1 LNX1 MAPK6 MAPT NEDD4 NTAQ1 NUAK1 PCYT1A PIN1 PKIA PPL PRKAB2 PRKCZ PSEN1 PSEN2 PSME3 RB1 SATB1 SP1 SRF SRP72 STUB1 TAB1 TFAP2A TOP1 TRAF1 UBE4A UBE4B VIM	23 interacting genes: BAZ1A CASP6 CBX4 CHD3 CUX1 EP300 GATA3 HDAC1 KAT2B MEOX2 MTA2 PIAS1 PIAS3 PIAS4 POLR2J SIRT1 SMARCA5 SPG21 SUMO1 SUMO1P1 TOPORS UBE2I UBR5
Entrez ID		839	6304
HPRD ID		03321	03647
Ensembl ID		ENSG00000138794	ENSG00000182568
Uniprot IDs		P55212	A0A024R2H1 Q01826
PDB IDs		1MI9 2WDP 3K7E 3NKF 3NR2 3OD5 3P45 3P4U 3QNW 3S70 3S8E 3V6L 3V6M 4EJF 4FXO 4HVA 4IYR 4N5D 4N6G 4N7J 4N7M 4NBK 4NBL 4NBN 6DEU 6DEV	1YSE 2L1P 2MW8 2O49 2O4A 3NZL 3TUO 6LFF
Enriched GO Terms of Interacting Partners?
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