WLS and GPR37

Data Source:
BioGRID (two hybrid)

		WLS	GPR37
Description		Wnt ligand secretion mediator	G protein-coupled receptor 37
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Endomembrane System Endocytic Vesicle Membrane Integral Component Of Organelle Membrane Cytoplasmic Vesicle Early Endosome Membrane Dendrite Membrane Dendrite Cytoplasm Extracellular Exosome	Ubiquitin Ligase Complex Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Receptor Complex
	Molecular Function	Protein Binding Wnt-protein Binding Mu-type Opioid Receptor Binding	G Protein-coupled Receptor Activity Protein Binding Neuropeptide Receptor Activity G Protein-coupled Peptide Receptor Activity Hsp70 Protein Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Prosaposin Receptor Activity Peptide Binding Neuropeptide Binding
	Biological Process	Intracellular Protein Transport Anterior/posterior Axis Specification Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Wnt Protein Secretion Positive Regulation Of Wnt Protein Secretion Positive Regulation Of Canonical Wnt Signaling Pathway	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Locomotion Involved In Locomotory Behavior Dopamine Biosynthetic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Dopamine Metabolic Process Negative Regulation Of Hydrogen Peroxide-induced Cell Death
Pathways		WNT ligand biogenesis and trafficking	Peptide ligand-binding receptors G alpha (i) signalling events
Drugs
Diseases
GWAS		Bone mineral density (spine) ( 26911590) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Femoral neck bone mineral density ( 29499414 32239398) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) Heel bone mineral density ( 30598549 28869591) Lumbar spine bone mineral density ( 29499414 22504420) Perceived intensity of sucrose ( 31005972) Postoperative complication after cardiac surgery ( 30678657) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Ankylosing spondylitis ( 23749187) Cutaneous malignant melanoma ( 32341527 26237428) Nevus count or cutaneous melanoma ( 32341527) Reading and spelling ( 23738518) Refractive error ( 32231278)
Interacting Genes		6 interacting genes: CCR2 DRD2 GPR37 HRH1 OPRM1 SMO	51 interacting genes: ADGRB1 ADORA2A ADRA1A ADRB2 BNIP3 CCNQ CNTN1 DRD2 ERGIC3 FA2H FKBP8 FUCA2 G6PC3 GABARAPL2 GABBR1 GHITM GLP1R GPR17 GRIP1 HDGF HLA-C HSP90B1 HSPA1A HTR2C HTR4 IFITM3 JKAMP LTB4R2 P4HTM PPM1J PRKN SDCBP SLC37A1 SLC3A2 SLC41A3 SLC8A2 SPATA2L STUB1 SYVN1 TAFA5 TMED1 TMEM161A TMEM175 TMEM231 TMEM63A TTYH1 TTYH2 WLS YIF1A YIF1B ZDHHC11
Entrez ID		79971	2861
HPRD ID		10980	03992
Ensembl ID		ENSG00000116729	ENSG00000170775
Uniprot IDs		Q5T9L3	O15354
PDB IDs
Enriched GO Terms of Interacting Partners?
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