GPR37 and CNTN1

Data Source:
BioGRID (two hybrid)

		GPR37	CNTN1
Description		G protein-coupled receptor 37	contactin 1
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Receptor Complex	Membrane Membrane Raft Extracellular Exosome Anchored Component Of Postsynaptic Membrane Anchored Component Of Presynaptic Membrane
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Neuropeptide Receptor Activity G Protein-coupled Peptide Receptor Activity Hsp70 Protein Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Prosaposin Receptor Activity Peptide Binding Neuropeptide Binding	Protein Binding Carbohydrate Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Locomotion Involved In Locomotory Behavior Dopamine Biosynthetic Process Positive Regulation Of MAPK Cascade Positive Regulation Of Dopamine Metabolic Process Negative Regulation Of Hydrogen Peroxide-induced Cell Death	Cell Adhesion Notch Signaling Pathway Positive Regulation Of Gene Expression Positive Regulation Of Sodium Ion Transport Positive Regulation Of Neuron Projection Development Cerebellum Development Neuron Projection Development Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	Activated NOTCH1 Transmits Signal to the Nucleus NOTCH2 Activation and Transmission of Signal to the Nucleus L1CAM interactions Neurofascin interactions
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 23749187) Cutaneous malignant melanoma ( 32341527 26237428) Nevus count or cutaneous melanoma ( 32341527) Reading and spelling ( 23738518) Refractive error ( 32231278)	Antidepressant treatment resistance (> 2 drugs prescribed) ( 30700811) Blood protein levels ( 30072576) Body mass index ( 26426971) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Dementia and core Alzheimer's disease neuropathologic changes ( 25188341) Metabolite levels (X-11787) ( 23934736) Motion sickness ( 25628336) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Pneumoconiosis in silica exposure ( 24986923) Protein quantitative trait loci ( 18464913)
Interacting Genes		51 interacting genes: ADGRB1 ADORA2A ADRA1A ADRB2 BNIP3 CCNQ CNTN1 DRD2 ERGIC3 FA2H FKBP8 FUCA2 G6PC3 GABARAPL2 GABBR1 GHITM GLP1R GPR17 GRIP1 HDGF HLA-C HSP90B1 HSPA1A HTR2C HTR4 IFITM3 JKAMP LTB4R2 P4HTM PPM1J PRKN SDCBP SLC37A1 SLC3A2 SLC41A3 SLC8A2 SPATA2L STUB1 SYVN1 TAFA5 TMED1 TMEM161A TMEM175 TMEM231 TMEM63A TTYH1 TTYH2 WLS YIF1A YIF1B ZDHHC11	14 interacting genes: CNTN2 FYN GPR37 L1CAM MAPK6 NOTCH1 NOTCH2 PPP1CA PRNP PTPRB SCN3A SCNN1B TNC TNR
Entrez ID		2861	1272
HPRD ID		03992	07189
Ensembl ID		ENSG00000170775	ENSG00000018236
Uniprot IDs		O15354	A0A024R104 Q12860
PDB IDs			2EE2 3S97
Enriched GO Terms of Interacting Partners?
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