WLS and CCR2

Data Source:
BioGRID (two hybrid)

		WLS	CCR2
Description		Wnt ligand secretion mediator	C-C motif chemokine receptor 2
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Endomembrane System Endocytic Vesicle Membrane Integral Component Of Organelle Membrane Cytoplasmic Vesicle Early Endosome Membrane Dendrite Membrane Dendrite Cytoplasm Extracellular Exosome	Cytoplasm Cytosol Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Dendrite Neuronal Cell Body Perikaryon Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding Wnt-protein Binding Mu-type Opioid Receptor Binding	Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding CCR2 Chemokine Receptor Binding Identical Protein Binding
	Biological Process	Intracellular Protein Transport Anterior/posterior Axis Specification Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Wnt Protein Secretion Positive Regulation Of Wnt Protein Secretion Positive Regulation Of Canonical Wnt Signaling Pathway	Blood Vessel Remodeling Dendritic Cell Chemotaxis Regulation Of T Cell Cytokine Production Positive Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Type 2 Immune Response Cellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Immune Response Cellular Defense Response G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Receptor Signaling Pathway Via JAK-STAT Response To Wounding Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of T Cell Chemotaxis Viral Process Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Sensory Perception Of Pain Calcium-mediated Signaling Cellular Homeostasis Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Tumor Necrosis Factor Production Monocyte Extravasation T-helper 17 Cell Chemotaxis Negative Regulation Of Eosinophil Degranulation Regulation Of T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of T Cell Activation Positive Regulation Of Synaptic Transmission, Glutamatergic Cell Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages Inflammatory Response To Wounding Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of NMDA Glutamate Receptor Activity Macrophage Migration Positive Regulation Of Thymocyte Migration Positive Regulation Of Monocyte Extravasation Positive Regulation Of CD8-positive, Alpha-beta T Cell Extravasation Positive Regulation Of Astrocyte Chemotaxis Positive Regulation Of Hematopoietic Stem Cell Migration
Pathways		WNT ligand biogenesis and trafficking	Beta defensins Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling
Drugs			INCB3284 CCX915 Plozalizumab
Diseases
GWAS		Bone mineral density (spine) ( 26911590) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Femoral neck bone mineral density ( 29499414 32239398) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398) Heel bone mineral density ( 30598549 28869591) Lumbar spine bone mineral density ( 29499414 22504420) Perceived intensity of sucrose ( 31005972) Postoperative complication after cardiac surgery ( 30678657) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)	Blood protein levels ( 28240269 23696881) Celiac disease ( 22057235 20190752 25920553 24999842) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 26192919) Monocyte count ( 29403010 27863252) Monocyte percentage of white cells ( 32888494 27863252) Obesity-related traits ( 23251661) Rheumatoid arthritis ( 32868391) Ulcerative colitis ( 26192919 28067908)
Interacting Genes		6 interacting genes: CCR2 DRD2 GPR37 HRH1 OPRM1 SMO	40 interacting genes: APP ARL6IP5 ATP2B1 B3GAT3 BLOC1S6 CACYBP CD59 CD81 CDIP1 CLPTM1 DMWD EMC10 ERGIC3 GOT1 GPR161 HERPUD1 HMOX2 JPH3 NDFIP1 NOTCH2 NTNG2 PCMT1 PLLP PTPN9 RGR RHOG RTN3 S1PR5 SCG5 SLC2A1 SLC41A3 SRSF5 SUMO1 SVOP TECPR2 TMEM161A TMEM199 TMEM63A TSPAN7 WLS
Entrez ID		79971	729230
HPRD ID		10980	19667
Ensembl ID		ENSG00000116729	ENSG00000121807
Uniprot IDs		Q5T9L3	A0A024R2Q0 P41597
PDB IDs			1KAD 1KP1 2MLO 2MLQ 5T1A
Enriched GO Terms of Interacting Partners?
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