PDZD3 and SLC22A4

Data Source:
HPRD (two hybrid)

		PDZD3	SLC22A4
Description		PDZ domain containing 3	solute carrier family 22 member 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Brush Border Apical Plasma Membrane Apical Junction Complex Apical Part Of Cell	Mitochondrion Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane
	Molecular Function	Protein Binding Protein C-terminus Binding Ion Channel Inhibitor Activity Guanylate Cyclase Inhibitor Activity Protein-membrane Adaptor Activity Ubiquitin-specific Protease Binding	Nucleotide Binding Protein Binding ATP Binding Secondary Active Organic Cation Transmembrane Transporter Activity Amino Acid Transmembrane Transporter Activity Carnitine Transmembrane Transporter Activity Symporter Activity Cation:cation Antiporter Activity Quaternary Ammonium Group Transmembrane Transporter Activity PDZ Domain Binding
	Biological Process	Ion Transport Water Transport Receptor Guanylyl Cyclase Signaling Pathway Response To Toxic Substance Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Guanylate Cyclase Activity Protein Localization To Plasma Membrane	Triglyceride Metabolic Process Sodium Ion Transport Body Fluid Secretion Carnitine Metabolic Process Organic Cation Transport Quaternary Ammonium Group Transport Carnitine Transport Xenobiotic Transport Amino Acid Import Across Plasma Membrane Carnitine Transmembrane Transport
Pathways		Intestinal infectious diseases	Organic cation transport
Drugs			Levocarnitine
Diseases			Crohn's disease
GWAS			Acylcarnitine levels ( 26068415) Asthma ( 31619474) Asthma (sex interaction) ( 24824216) Asthma or allergic disease (pleiotropy) ( 29785011) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Brain morphology (MOSTest) ( 32665545) Coronary artery disease ( 29212778) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908 22412388 21102463) Estimated glomerular filtration rate ( 31152163) Fibrinogen ( 20031577) Fibrinogen levels ( 26561523) Granulocyte count ( 27863252) Immature fraction of reticulocytes ( 27863252) Inflammatory bowel disease ( 28067908 23128233) Intracranial aneurysm ( 33199917) Itch intensity from mosquito bite ( 28199695) Lymphocyte counts ( 32888494) Mean platelet volume ( 27863252) Metabolic traits ( 21886157) Monocyte count ( 32888494 27863252) Myeloid white cell count ( 27863252) Nasal polyps ( 30643255) Neutrophil count ( 27863252) Platelet count ( 32888494) Serum metabolite levels ( 23093944) Subcortical volume (MOSTest) ( 32665545) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Ulcerative colitis ( 28067908) Urinary albumin-to-creatinine ratio ( 31511532) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412) White blood cell count ( 27863252)
Interacting Genes		18 interacting genes: ABCC2 ASAP3 CACNA1S CFTR GUCY2C PTGIR SLC15A1 SLC15A2 SLC22A3 SLC22A4 SLC22A5 SLC22A9 SLC41A3 SLCO1A2 SLCO1C1 SLCO3A1 SPRYD7 TAS2R8	4 interacting genes: PDZD3 PDZK1 SLC9A3R1 SLC9A3R2
Entrez ID		79849	6583
HPRD ID		06191	09171
Ensembl ID		ENSG00000172367	ENSG00000197208
Uniprot IDs		B0YJ61 Q86UT5	Q9H015
PDB IDs		2V90
Enriched GO Terms of Interacting Partners?
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