PDZD3 and SLC22A3

Data Source:
HPRD (two hybrid)

		PDZD3	SLC22A3
Description		PDZ domain containing 3	solute carrier family 22 member 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Brush Border Apical Plasma Membrane Apical Junction Complex Apical Part Of Cell	Plasma Membrane Integral Component Of Plasma Membrane Membrane Neuronal Cell Body Presynapse
	Molecular Function	Protein Binding Protein C-terminus Binding Ion Channel Inhibitor Activity Guanylate Cyclase Inhibitor Activity Protein-membrane Adaptor Activity Ubiquitin-specific Protease Binding	Neurotransmitter Transmembrane Transporter Activity Dopamine:sodium Symporter Activity Protein Binding Monoamine Transmembrane Transporter Activity Organic Anion Transmembrane Transporter Activity Organic Cation Transmembrane Transporter Activity Quaternary Ammonium Group Transmembrane Transporter Activity Toxin Transmembrane Transporter Activity
	Biological Process	Ion Transport Water Transport Receptor Guanylyl Cyclase Signaling Pathway Response To Toxic Substance Negative Regulation Of CGMP-mediated Signaling Negative Regulation Of Guanylate Cyclase Activity Protein Localization To Plasma Membrane	Histamine Metabolic Process Neurotransmitter Transport Drug Transmembrane Transport Organic Cation Transport Quaternary Ammonium Group Transport Organic Anion Transport Monocarboxylic Acid Transport Monoamine Transport Regulation Of Appetite Xenobiotic Transport Serotonin Uptake Histamine Uptake Norepinephrine Uptake Epinephrine Uptake Dopamine Uptake Transport Across Blood-brain Barrier Toxin Transport
Pathways		Intestinal infectious diseases	Abacavir transmembrane transport Organic cation transport
Drugs
Diseases
GWAS			Body mass index ( 26426971 28892062) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Colorectal cancer ( 21242260) Coronary artery disease ( 24262325 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or ischemic stroke ( 24262325) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 19198611) Estimated glomerular filtration rate ( 31015462) Glycine levels ( 30837465) Height ( 31562340) Lipoprotein (a) levels ( 26377243) Lipoprotein (a) levels in response to niacin in statin-treated individuals ( 30371334) Lp (a) levels ( 21900290) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte percentage of white cells ( 32888494) Plasma plasminogen levels ( 25208887) Prostate cancer ( 18264097 26034056 25939597 27262462) Pulse pressure ( 30224653) Response to hepatitis C treatment ( 22095909) Type 2 diabetes ( 30054458 30297969 28869590)
Interacting Genes		18 interacting genes: ABCC2 ASAP3 CACNA1S CFTR GUCY2C PTGIR SLC15A1 SLC15A2 SLC22A3 SLC22A4 SLC22A5 SLC22A9 SLC41A3 SLCO1A2 SLCO1C1 SLCO3A1 SPRYD7 TAS2R8	1 interacting genes: PDZD3
Entrez ID		79849	6581
HPRD ID		06191	05328
Ensembl ID		ENSG00000172367	ENSG00000146477
Uniprot IDs		B0YJ61 Q86UT5	O75751
PDB IDs		2V90
Enriched GO Terms of Interacting Partners?
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