PLA2G2A and PLA2G1B

Data Source:
HPRD (in vitro)

		PLA2G2A	PLA2G1B
Description		phospholipase A2 group IIA	phospholipase A2 group IB
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Secretory Granule Perinuclear Region Of Cytoplasm Extracellular Exosome	Extracellular Region Extracellular Space Cell Surface Secretory Granule
	Molecular Function	Phospholipase A2 Activity Calcium Ion Binding Phospholipid Binding Calcium-dependent Phospholipase A2 Activity Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine) Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine)	Phospholipase A2 Activity Signaling Receptor Binding Calcium Ion Binding Bile Acid Binding Calcium-dependent Phospholipase A2 Activity Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine) Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine)
	Biological Process	Phospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Inflammatory Response Positive Regulation Of Macrophage Derived Foam Cell Differentiation Lipid Catabolic Process Antimicrobial Humoral Response Cytolysis Low-density Lipoprotein Particle Remodeling Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylinositol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Intestinal Stem Cell Homeostasis Phosphatidylethanolamine Metabolic Process Phosphatidylcholine Metabolic Process Phosphatidic Acid Metabolic Process Arachidonic Acid Secretion Positive Regulation Of Inflammatory Response Defense Response To Gram-positive Bacterium Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Neutrophil Activation	Activation Of MAPK Activity Innate Immune Response In Mucosa Neutrophil Mediated Immunity Fatty Acid Biosynthetic Process Phosphatidic Acid Biosynthetic Process Actin Filament Organization Signal Transduction Positive Regulation Of Cell Population Proliferation Positive Regulation Of Calcium Ion Transport Into Cytosol Lipid Catabolic Process Leukotriene Biosynthetic Process Antibacterial Humoral Response Neutrophil Chemotaxis Activation Of Phospholipase A2 Activity Positive Regulation Of Interleukin-8 Production Cellular Response To Insulin Stimulus Intracellular Signal Transduction Phosphatidylglycerol Acyl-chain Remodeling Phosphatidylinositol Acyl-chain Remodeling Phosphatidylserine Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Phosphatidylethanolamine Acyl-chain Remodeling Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Glucose Import Phosphatidylcholine Metabolic Process Phosphatidylglycerol Metabolic Process Positive Regulation Of Fibroblast Proliferation Arachidonic Acid Secretion Positive Regulation Of Protein Secretion Positive Regulation Of Immune Response Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of Glomerular Visceral Epithelial Cell Apoptotic Process
Pathways		Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA Antimicrobial peptides	Acyl chain remodelling of PC Acyl chain remodelling of PS Acyl chain remodelling of PE Acyl chain remodelling of PI Acyl chain remodelling of PG Synthesis of PA
Drugs		Indomethacin Ginkgo biloba 1,4-Butanediol 1-{2-[2-(2-Methoxyethoxy)Ethoxy]Ethoxy}-4-(1,1,3,3-Tetramethylbutyl)Benzene N-Tridecanoic Acid [3-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Propyl-]-Phosphonic Acid 4-(1-Benzyl-3-Carbamoylmethyl-2-Methyl-1h-Indol-5-Yloxy)-Butyric Acid Lauric acid (1-Benzyl-5-methoxy-2-methyl-1H-indol-3-yl)acetic acid 6-phenyl-4(R)-(7-phenyl-heptanoylamino)-hexanoic acid Elaidamide (2R)-2-Acetamido-3-(octadecyloxy)propyl 2-(methylsulfanyl)ethyl hydrogen phosphate KH064 Suramin Varespladib methyl	Sulfasalazine Azelastine Hexane-1,6-Diol N-Tridecanoic Acid Cholic Acid P-Anisic Acid Heptanoic acid 1-O-Octyl-2-Heptylphosphonyl-Sn-Glycero-3-Phosphoethanolamine Pyruvaldehyde Lpc-Ether Niflumic acid PHOSPHONIC ACID 2-DODECANOYLAMINO-HEXYL ESTER PROPYL ESTER 1-DECYL-3-TRIFLUORO ETHYL-SN-GLYCERO-2-PHOSPHOMETHANOL Medical Cannabis
Diseases
GWAS		Blood protein levels ( 30072576 29875488) group IIA secretory phospholipase A2 levels in individuals with elevated hsCRP ( 31070471) Immunoglobulin light chain (AL) amyloidosis ( 28025584)	Bipolar disorder ( 31043756)
Interacting Genes		26 interacting genes: ALOX12 BAG6 CEP70 CRMP1 DCN ITGAV ITGB3 JOSD2 PLA2G1B PLA2R1 SENP6 SENP8 UCHL1 UCHL3 UCHL5 USP15 USP2 USP20 USP28 USP4 USP47 USP5 USP7 USP8 VCAN VIM	5 interacting genes: BGN CSF3R PLA2G2A PLAA SOCS2
Entrez ID		5320	5319
HPRD ID		01397	01396
Ensembl ID		ENSG00000188257	ENSG00000170890
Uniprot IDs		A0A024RA96 P14555	P04054
PDB IDs		1AYP 1BBC 1DB4 1DB5 1DCY 1J1A 1KQU 1KVO 1N28 1N29 1POD 1POE 2GNY 3U8B 3U8D 3U8H 3U8I 5G3N	1YSK 3ELO 6Q42
Enriched GO Terms of Interacting Partners?
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