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UBE3A and SPINK1
Data Source:
BioGRID
(pull down)
UBE3A
SPINK1
Description
ubiquitin protein ligase E3A
serine peptidase inhibitor Kazal type 1
Image
GO Annotations
Cellular Component
Proteasome Complex
Nucleus
Cytosol
Extracellular Exosome
Molecular Function
Transcription Coactivator Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Endopeptidase Inhibitor Activity
Serine-type Endopeptidase Inhibitor Activity
Protein Binding
Biological Process
Ovarian Follicle Development
Proteolysis
Ubiquitin-dependent Protein Catabolic Process
Brain Development
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Viral Process
Androgen Receptor Signaling Pathway
Positive Regulation Of Protein Ubiquitination
Response To Progesterone
Sperm Entry
Response To Cocaine
Response To Hydrogen Peroxide
Regulation Of Circadian Rhythm
Positive Regulation Of Transcription By RNA Polymerase II
Rhythmic Process
Progesterone Receptor Signaling Pathway
Protein Autoubiquitination
Prostate Gland Growth
Negative Regulation Of Dendritic Spine Morphogenesis
Protein K48-linked Ubiquitination
Positive Regulation Of Golgi Lumen Acidification
Cellular Response To Brain-derived Neurotrophic Factor Stimulus
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of Nitric Oxide Mediated Signal Transduction
Sperm Capacitation
Negative Regulation Of Peptidyl-tyrosine Phosphorylation
Regulation Of Acrosome Reaction
Negative Regulation Of Calcium Ion Import
Negative Regulation Of Serine-type Endopeptidase Activity
Regulation Of Store-operated Calcium Entry
Pathways
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)
Tropical calcific pancreatitis
Hereditary pancreatitis; Hereditary chronic pancreatitis
GWAS
Cardiac hypertrophy (
21348951
)
Gene methylation in lung tissue (
25713168
)
Obesity-related traits (
23251661
)
Alcoholic chronic pancreatitis (
28754779
)
Blood protein levels (
30072576
)
Metabolite levels (
23823483
)
Obesity-related traits (
23251661
)
Interacting Genes
125 interacting genes:
ACTA2
ACTB
ACTBL2
ACTR3
ADRM1
AFG3L1P
AFTPH
AHSP
ANXA1
APP
AR
ARC
ARHGDIB
ASAP3
ATG9A
BARD1
BLK
BPY2
BPY2B
BPY2C
BRCA1
C11orf49
CALR
CDK1
CDK4
CDKN1B
CEBPZ
CGGBP1
CTNNB1
DAZAP2
DLG1
E2F1
EAPP
EID1
EIF4G1
FAF2
GFAP
GTF3C1
HBA1
HPCAL4
HSP90AB1
HSPA4
HSPA5
JADE1
KLHL38
KRT1
KRT5
KRT7
KRT9
LCK
MAGEA12
MAGEA8
MAPK1
MARF1
MCM6
MCM7
MDM1
MDM2
MEOX2
NBPF14
NDUFA13
NELFCD
NOMO2
NR4A3
PARVA
PAX5
PAX6
PDE1B
PDIA3
PDIA6
PGR
PML
POLE4
PRAG1
PRDX1
PRKACA
PRMT5
PSAP
PTCD3
RAD23A
RAD23B
RARA
RMI1
RPS15A
RYBP
SACS
SCAMP1
SCRIB
SHBG
SIRT6
SMAD9
SNAPC3
SOD1
SPINK1
SUMO3
TALDO1
TAT
TBC1D14
TCF19
TMEM14B
TP53
TP53BP2
TRIM65
TSC2
TTC23L
TTC3
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2G1
UBE2G2
UBE2L3
UBE2L6
UBE2N
UBQLN1
UBQLN2
WBP2
YOD1
YWHAE
YWHAG
YWHAZ
ZNF250
ZNF446
6 interacting genes:
ASPH
CTRC
ELN
NRSN1
TMPRSS15
UBE3A
Entrez ID
7337
6690
HPRD ID
03375
01341
Ensembl ID
ENSG00000114062
ENSG00000164266
Uniprot IDs
Q05086
Q9H2G0
P00995
PDB IDs
1C4Z
1D5F
1EQX
2KR1
4GIZ
4XR8
6SJV
6SLM
6TGK
6U19
1CGI
1CGJ
1HPT
Enriched GO Terms of Interacting Partners
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