UBE3A and PDE1B

Data Source:
BioGRID (two hybrid)

		UBE3A	PDE1B
Description		ubiquitin protein ligase E3A	phosphodiesterase 1B
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GO Annotations	Cellular Component	Proteasome Complex Nucleus Cytosol	Cytosol Neuronal Cell Body
	Molecular Function	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Calmodulin-dependent Cyclic-nucleotide Phosphodiesterase Activity Protein Binding Calmodulin Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity Calcium- And Calmodulin-regulated 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Ovarian Follicle Development Proteolysis Ubiquitin-dependent Protein Catabolic Process Brain Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Androgen Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Response To Progesterone Sperm Entry Response To Cocaine Response To Hydrogen Peroxide Regulation Of Circadian Rhythm Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Progesterone Receptor Signaling Pathway Protein Autoubiquitination Prostate Gland Growth Negative Regulation Of Dendritic Spine Morphogenesis Protein K48-linked Ubiquitination Positive Regulation Of Golgi Lumen Acidification Cellular Response To Brain-derived Neurotrophic Factor Stimulus Regulation Of Ubiquitin-dependent Protein Catabolic Process	Regulation Of Neurotransmitter Levels Response To Amphetamine Apoptotic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Locomotory Behavior Visual Learning Monocyte Differentiation Cellular Response To Macrophage Colony-stimulating Factor Stimulus Regulation Of Dopamine Metabolic Process Serotonin Metabolic Process Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Cam-PDE 1 activation cGMP effects G alpha (s) signalling events
Drugs			Caffeine Caffeine Nicardipine Felodipine Bepridil S,S-(2-Hydroxyethyl)Thiocysteine Trapidil
Diseases		Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)
GWAS		Cardiac hypertrophy ( 21348951) Gene methylation in lung tissue ( 25713168) Obesity-related traits ( 23251661)	Post bronchodilator FEV1 in COPD ( 26634245)
Interacting Genes		125 interacting genes: ACTA2 ACTB ACTBL2 ACTR3 ADRM1 AFG3L1P AFTPH AHSP ANXA1 APP AR ARC ARHGDIB ASAP3 ATG9A BARD1 BLK BPY2 BPY2B BPY2C BRCA1 C11orf49 CALR CDK1 CDK4 CDKN1B CEBPZ CGGBP1 CTNNB1 DAZAP2 DLG1 E2F1 EAPP EID1 EIF4G1 FAF2 GFAP GTF3C1 HBA1 HPCAL4 HSP90AB1 HSPA4 HSPA5 JADE1 KLHL38 KRT1 KRT5 KRT7 KRT9 LCK MAGEA12 MAGEA8 MAPK1 MARF1 MCM6 MCM7 MDM1 MDM2 MEOX2 NBPF14 NDUFA13 NELFCD NOMO2 NR4A3 PARVA PAX5 PAX6 PDE1B PDIA3 PDIA6 PGR PML POLE4 PRAG1 PRDX1 PRKACA PRMT5 PSAP PTCD3 RAD23A RAD23B RARA RMI1 RPS15A RYBP SACS SCAMP1 SCRIB SHBG SIRT6 SMAD9 SNAPC3 SOD1 SPINK1 SUMO3 TALDO1 TAT TBC1D14 TCF19 TMEM14B TP53 TP53BP2 TRIM65 TSC2 TTC23L TTC3 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2G1 UBE2G2 UBE2L3 UBE2L6 UBE2N UBQLN1 UBQLN2 WBP2 YOD1 YWHAE YWHAG YWHAZ ZNF250 ZNF446	2 interacting genes: POT1 UBE3A
Entrez ID		7337	5153
HPRD ID		03375	01388
Ensembl ID		ENSG00000114062	ENSG00000123360
Uniprot IDs		Q05086 Q9H2G0	A0A024RB59 B3KX78 B4DK72 Q01064 Q7Z364
PDB IDs		1C4Z 1D5F 1EQX 2KR1 4GIZ 4XR8 6SJV 6SLM 6TGK 6U19	1LXR 1TAZ 4NPV 4NPW 5B25 5UOY 5UP0 5W6E
Enriched GO Terms of Interacting Partners?
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