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UBE3A and PSAP
Data Source:
BioGRID
(two hybrid)
UBE3A
PSAP
Description
ubiquitin protein ligase E3A
prosaposin
Image
GO Annotations
Cellular Component
Proteasome Complex
Nucleus
Cytosol
Extracellular Region
Extracellular Space
Lysosome
Lysosomal Membrane
Late Endosome
Plasma Membrane
Azurophil Granule Membrane
Lysosomal Lumen
Intracellular Membrane-bounded Organelle
Collagen-containing Extracellular Matrix
Extracellular Exosome
Molecular Function
Transcription Coactivator Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Protease Binding
Beta-galactosidase Activity
Protein Binding
Phospholipid Binding
Enzyme Activator Activity
Lipid Binding
Protein Homodimerization Activity
Ganglioside GM1 Binding
Ganglioside GM2 Binding
Ganglioside GM3 Binding
Ganglioside GT1b Binding
Ganglioside GP1c Binding
Biological Process
Ovarian Follicle Development
Proteolysis
Ubiquitin-dependent Protein Catabolic Process
Brain Development
Positive Regulation Of Phosphatidylinositol 3-kinase Signaling
Viral Process
Androgen Receptor Signaling Pathway
Positive Regulation Of Protein Ubiquitination
Response To Progesterone
Sperm Entry
Response To Cocaine
Response To Hydrogen Peroxide
Regulation Of Circadian Rhythm
Positive Regulation Of Transcription By RNA Polymerase II
Rhythmic Process
Progesterone Receptor Signaling Pathway
Protein Autoubiquitination
Prostate Gland Growth
Negative Regulation Of Dendritic Spine Morphogenesis
Protein K48-linked Ubiquitination
Positive Regulation Of Golgi Lumen Acidification
Cellular Response To Brain-derived Neurotrophic Factor Stimulus
Regulation Of Ubiquitin-dependent Protein Catabolic Process
Platelet Degranulation
Glycosphingolipid Metabolic Process
Lipid Transport
Lysosomal Transport
G Protein-coupled Receptor Signaling Pathway
Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway
Regulation Of Autophagy
Regulation Of Lipid Metabolic Process
Neutrophil Degranulation
Regulation Of Catalytic Activity
Prostate Gland Growth
Epithelial Cell Differentiation Involved In Prostate Gland Development
Ganglioside GM1 Transport To Membrane
Pathways
Antigen processing: Ubiquitination & Proteasome degradation
Platelet degranulation
Glycosphingolipid metabolism
Peptide ligand-binding receptors
G alpha (i) signalling events
Neutrophil degranulation
Drugs
Di-Stearoyl-3-Sn-Phosphatidylethanolamine
Diseases
Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)
Krabbe disease; Globoid cell leukodystrophy
Metachromatic leukodystrophy (MLD)
Gaucher disease
GWAS
Cardiac hypertrophy (
21348951
)
Gene methylation in lung tissue (
25713168
)
Obesity-related traits (
23251661
)
Asthma (childhood onset) (
23829686
)
Seasonality and depression (
30217971
)
Interacting Genes
125 interacting genes:
ACTA2
ACTB
ACTBL2
ACTR3
ADRM1
AFG3L1P
AFTPH
AHSP
ANXA1
APP
AR
ARC
ARHGDIB
ASAP3
ATG9A
BARD1
BLK
BPY2
BPY2B
BPY2C
BRCA1
C11orf49
CALR
CDK1
CDK4
CDKN1B
CEBPZ
CGGBP1
CTNNB1
DAZAP2
DLG1
E2F1
EAPP
EID1
EIF4G1
FAF2
GFAP
GTF3C1
HBA1
HPCAL4
HSP90AB1
HSPA4
HSPA5
JADE1
KLHL38
KRT1
KRT5
KRT7
KRT9
LCK
MAGEA12
MAGEA8
MAPK1
MARF1
MCM6
MCM7
MDM1
MDM2
MEOX2
NBPF14
NDUFA13
NELFCD
NOMO2
NR4A3
PARVA
PAX5
PAX6
PDE1B
PDIA3
PDIA6
PGR
PML
POLE4
PRAG1
PRDX1
PRKACA
PRMT5
PSAP
PTCD3
RAD23A
RAD23B
RARA
RMI1
RPS15A
RYBP
SACS
SCAMP1
SCRIB
SHBG
SIRT6
SMAD9
SNAPC3
SOD1
SPINK1
SUMO3
TALDO1
TAT
TBC1D14
TCF19
TMEM14B
TP53
TP53BP2
TRIM65
TSC2
TTC23L
TTC3
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2G1
UBE2G2
UBE2L3
UBE2L6
UBE2N
UBQLN1
UBQLN2
WBP2
YOD1
YWHAE
YWHAG
YWHAZ
ZNF250
ZNF446
20 interacting genes:
APPBP2
BACE1
BRCA1
CD1B
CELSR1
COPS6
CPEB2
CTSD
ERBB2
GBA
MAFF
NLGN3
PEX5
PRAG1
SGCG
SMAD2
SMAD9
UBE3A
USP4
ZBED1
Entrez ID
7337
5660
HPRD ID
03375
01460
Ensembl ID
ENSG00000114062
ENSG00000197746
Uniprot IDs
Q05086
Q9H2G0
A0A024QZQ2
P07602
PDB IDs
1C4Z
1D5F
1EQX
2KR1
4GIZ
4XR8
6SJV
6SLM
6TGK
6U19
1M12
1N69
1SN6
2DOB
2GTG
2QYP
2R0R
2R1Q
2RB3
2Z9A
3BQP
3BQQ
4DDJ
4UEX
4V2O
6SLR
Enriched GO Terms of Interacting Partners
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