SERPING1 and C1R

Data Source:
BioGRID (biochemical)
HPRD (in vitro)

		SERPING1	C1R
Description		serpin family G member 1	complement C1r
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Extracellular Region Extracellular Space Extracellular Exosome Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Serine-type Peptidase Activity Identical Protein Binding
	Biological Process	Negative Regulation Of Complement Activation, Lectin Pathway Platelet Degranulation Complement Activation, Classical Pathway Blood Coagulation, Intrinsic Pathway Blood Circulation Negative Regulation Of Endopeptidase Activity Regulation Of Complement Activation Fibrinolysis Innate Immune Response	Immune Response Complement Activation Complement Activation, Classical Pathway Regulation Of Complement Activation Zymogen Activation Innate Immune Response
Pathways		Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Defective SERPING1 causes hereditary angioedema Regulation of Complement cascade	Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade
Drugs		PPL-100 Copper	Palivizumab Daclizumab Zinc Human C1-esterase inhibitor Conestat alfa Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency Hereditary angioedema	Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 29875488 28240269) Mean platelet volume ( 32888494) Neuroticism ( 29255261) Obesity-related traits ( 23251661) Platelet count ( 32888494) Schizophrenia ( 25056061 29483656)
Interacting Genes		15 interacting genes: BAG6 C1R C1S ELANE ENO1 F2 MASP1 MASP2 NR4A1 PLAT PLG SELE SELP SLC30A2 SRPK2	7 interacting genes: C1QA C1QB C1S CSNK2A1 EP300 PCK1 SERPING1
Entrez ID		710	715
HPRD ID		06033	01954
Ensembl ID		ENSG00000149131	ENSG00000159403
Uniprot IDs		E9KL26 P05155	P00736
PDB IDs		1M6Q 2OAY 5DU3 5DUQ	1APQ 1GPZ 1MD7 1MD8 2QY0 6F1C 6F1D 6F1H 6F39
Enriched GO Terms of Interacting Partners?
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