C1R and C1S

Data Source:
HPRD (in vivo, in vitro)

		C1R	C1S
Description		complement C1r	complement C1s
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Exosome Blood Microparticle	Extracellular Region Extracellular Space Blood Microparticle
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Serine-type Peptidase Activity Identical Protein Binding	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Identical Protein Binding
	Biological Process	Immune Response Complement Activation Complement Activation, Classical Pathway Regulation Of Complement Activation Zymogen Activation Innate Immune Response	Proteolysis Complement Activation Complement Activation, Classical Pathway Regulation Of Complement Activation Innate Immune Response
Pathways		Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade	Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade
Drugs		Palivizumab Daclizumab Zinc Human C1-esterase inhibitor Conestat alfa Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Zinc 2-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Ethanesulfonic Acid Human C1-esterase inhibitor Copper Conestat alfa Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency	Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS			Activated partial thromboplastin time ( 29403010) Blood protein levels ( 29875488 28240269) Coronary artery disease ( 29212778 33020668) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Lung cancer in never smokers ( 28604730) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red blood cell fatty acid levels ( 25500335) Red cell distribution width ( 32888494 27863252) Refractive error ( 32231278)
Interacting Genes		7 interacting genes: C1QA C1QB C1S CSNK2A1 EP300 PCK1 SERPING1	5 interacting genes: C1QA C1R REEP4 SERPING1 VKORC1
Entrez ID		715	716
HPRD ID		01954	00397
Ensembl ID		ENSG00000159403	ENSG00000182326
Uniprot IDs		P00736	F8WCZ6 P09871
PDB IDs		1APQ 1GPZ 1MD7 1MD8 2QY0 6F1C 6F1D 6F1H 6F39	1ELV 1NZI 4J1Y 4LMF 4LOR 4LOS 4LOT 6F1C 6F1H
Enriched GO Terms of Interacting Partners?
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