C1R and C1QB

Data Source:
HPRD (in vivo)

		C1R	C1QB
Description		complement C1r	complement C1q B chain
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Extracellular Exosome Blood Microparticle	Extracellular Region Collagen Trimer Complement Component C1 Complex Synapse Collagen-containing Extracellular Matrix Blood Microparticle Postsynapse
	Molecular Function	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Serine-type Peptidase Activity Identical Protein Binding	Protein Binding
	Biological Process	Immune Response Complement Activation Complement Activation, Classical Pathway Regulation Of Complement Activation Zymogen Activation Innate Immune Response	Complement Activation Complement Activation, Classical Pathway Regulation Of Complement Activation Innate Immune Response Synapse Pruning
Pathways		Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade	Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade
Drugs		Palivizumab Daclizumab Zinc Human C1-esterase inhibitor Conestat alfa Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Cetuximab Etanercept Palivizumab Daclizumab Bevacizumab Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency	Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS
Interacting Genes		7 interacting genes: C1QA C1QB C1S CSNK2A1 EP300 PCK1 SERPING1	11 interacting genes: C1QA C1QC C1R DEFA1 EDA2R HRG IL32 MYOC PTX3 RELA UBQLN2
Entrez ID		715	713
HPRD ID		01954	00394
Ensembl ID		ENSG00000159403	ENSG00000173369
Uniprot IDs		P00736	A0A024RAB9 P02746
PDB IDs		1APQ 1GPZ 1MD7 1MD8 2QY0 6F1C 6F1D 6F1H 6F39	1PK6 2JG8 2JG9 2WNU 2WNV 5HKJ 5HZF 6FCZ 6Z6V
Enriched GO Terms of Interacting Partners?
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