SERPING1 and ENO1

Data Source:
BioGRID (two hybrid)

		SERPING1	ENO1
Description		serpin family G member 1	enolase 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Phosphopyruvate Hydratase Complex Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Cell Surface Membrane M Band Extracellular Exosome Cell Cortex Region
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding	Magnesium Ion Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific RNA Binding Phosphopyruvate Hydratase Activity Protein Binding Protein Homodimerization Activity Cadherin Binding GTPase Binding
	Biological Process	Negative Regulation Of Complement Activation, Lectin Pathway Platelet Degranulation Complement Activation, Classical Pathway Blood Coagulation, Intrinsic Pathway Blood Circulation Negative Regulation Of Endopeptidase Activity Regulation Of Complement Activation Fibrinolysis Innate Immune Response	Negative Regulation Of Transcription By RNA Polymerase II Gluconeogenesis Glycolytic Process Response To Virus Positive Regulation Of Plasminogen Activation Negative Regulation Of Cell Growth Regulation Of Vacuole Fusion, Non-autophagic Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Muscle Contraction Canonical Glycolysis Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of ATP Biosynthetic Process
Pathways		Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Defective SERPING1 causes hereditary angioedema Regulation of Complement cascade	Glycolysis Gluconeogenesis Manipulation of host energy metabolism
Drugs		PPL-100 Copper	Zinc Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency Hereditary angioedema
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 29875488 28240269) Mean platelet volume ( 32888494) Neuroticism ( 29255261) Obesity-related traits ( 23251661) Platelet count ( 32888494) Schizophrenia ( 25056061 29483656)	Asthma ( 30929738) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blood protein levels ( 30072576) Feeling tense ( 29500382) Platelet count ( 32888494) Plateletcrit ( 32888494 27863252) Tonsillectomy ( 27182965 28928442) White blood cell count ( 32888494) White blood cell count (basophil) ( 27863252)
Interacting Genes		15 interacting genes: BAG6 C1R C1S ELANE ENO1 F2 MASP1 MASP2 NR4A1 PLAT PLG SELE SELP SLC30A2 SRPK2	59 interacting genes: AGTPBP1 ALDOA AMBP ARID1B BCL6 BHLHE40 BRCA1 CBX5 CHEK2 CLK1 COL14A1 CYSLTR2 DES DUX4 FANCA FHL1 FLNC FYN GLIS3 GRB2 HDAC1 HEMGN HEY2 HK2 HSP90AB1 HSPA8 HSPB2 ITGB1 IVNS1ABP KDM2A LIG4 LINC01554 LONRF3 MCPH1 MED13 MYOC NCOR1 P4HB PAF1 PCNA PLG PPP2R5E RXFP3 SERPING1 SET SGCG SNAPC3 SRC SUMO2 SUMO4 TCAP TEAD1 TERT TRAPPC2 TTN UPF2 YWHAQ YWHAZ ZBTB44
Entrez ID		710	2023
HPRD ID		06033	01400
Ensembl ID		ENSG00000149131	ENSG00000074800
Uniprot IDs		E9KL26 P05155	A0A024R4F1 P06733
PDB IDs		1M6Q 2OAY 5DU3 5DUQ	2PSN 3B97 5JLZ 5LAX 5NI9 5NIG 5OCK
Enriched GO Terms of Interacting Partners?
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