SERPING1 and MASP1

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		SERPING1	MASP1
Description		serpin family G member 1	MBL associated serine protease 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Extracellular Region Extracellular Space Nucleoplasm Cytosol
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Protein Homodimerization Activity Calcium-dependent Protein Binding
	Biological Process	Negative Regulation Of Complement Activation, Lectin Pathway Platelet Degranulation Complement Activation, Classical Pathway Blood Coagulation, Intrinsic Pathway Blood Circulation Negative Regulation Of Endopeptidase Activity Regulation Of Complement Activation Fibrinolysis Innate Immune Response	Complement Activation, Lectin Pathway Proteolysis Receptor-mediated Endocytosis Complement Activation
Pathways		Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Defective SERPING1 causes hereditary angioedema Regulation of Complement cascade	Lectin pathway of complement activation Initial triggering of complement Ficolins bind to repetitive carbohydrate structures on the target cell surface Scavenging by Class A Receptors
Drugs		PPL-100 Copper
Diseases		Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency Hereditary angioedema
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 29875488 28240269) Mean platelet volume ( 32888494) Neuroticism ( 29255261) Obesity-related traits ( 23251661) Platelet count ( 32888494) Schizophrenia ( 25056061 29483656)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Blood protein levels ( 30072576) Impulsivity (attentional) ( 30718321) Type 2 diabetes ( 30130595)
Interacting Genes		15 interacting genes: BAG6 C1R C1S ELANE ENO1 F2 MASP1 MASP2 NR4A1 PLAT PLG SELE SELP SLC30A2 SRPK2	16 interacting genes: C2 C3 FCN2 GADD45A GSK3B H2AX MAPK6 MAPK8IP2 MAPT MBL2 NCK2 NUDT21 RPS6KA3 RPS6KA6 SERPING1 UFD1
Entrez ID		710	5648
HPRD ID		06033	02749
Ensembl ID		ENSG00000149131	ENSG00000127241
Uniprot IDs		E9KL26 P05155	F8W876 P48740
PDB IDs		1M6Q 2OAY 5DU3 5DUQ	3DEM 3GOV 4AQB 4DJZ 4IGD 4IW4 4KKD
Enriched GO Terms of Interacting Partners?
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