SERPING1 and SELP

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		SERPING1	SELP
Description		serpin family G member 1	selectin P
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Platelet Dense Granule Membrane Platelet Alpha Granule Membrane
	Molecular Function	Serine-type Endopeptidase Inhibitor Activity Protein Binding	Lipopolysaccharide Binding Calcium Ion Binding Protein Binding Heparin Binding Sialic Acid Binding Fucose Binding Glycosphingolipid Binding Calcium-dependent Protein Binding Oligosaccharide Binding
	Biological Process	Negative Regulation Of Complement Activation, Lectin Pathway Platelet Degranulation Complement Activation, Classical Pathway Blood Coagulation, Intrinsic Pathway Blood Circulation Negative Regulation Of Endopeptidase Activity Regulation Of Complement Activation Fibrinolysis Innate Immune Response	Platelet Degranulation Positive Regulation Of Leukocyte Migration Inflammatory Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Positive Regulation Of Platelet Activation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Response To Lipopolysaccharide Regulation Of Integrin Activation Calcium-mediated Signaling Using Intracellular Calcium Source Defense Response To Gram-negative Bacterium Leukocyte Migration Leukocyte Tethering Or Rolling Positive Regulation Of Leukocyte Tethering Or Rolling
Pathways		Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Defective SERPING1 causes hereditary angioedema Regulation of Complement cascade	Platelet degranulation Cell surface interactions at the vascular wall
Drugs		PPL-100 Copper	Heparin N-acetyl-alpha-neuraminic acid Dalteparin Nadroparin Crizanlizumab
Diseases		Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency Hereditary angioedema
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 29875488 28240269) Mean platelet volume ( 32888494) Neuroticism ( 29255261) Obesity-related traits ( 23251661) Platelet count ( 32888494) Schizophrenia ( 25056061 29483656)	Activated partial thromboplastin time ( 22703881) Blood protein levels ( 30072576 29875488 28240269) Hippocampal atrophy ( 22745009) Inflammatory bowel disease ( 26192919) L-selectin levels ( 25576479) Late-onset Alzheimer's disease ( 27770636) Optic disc size ( 31809533) Soluble levels of adhesion molecules ( 20167578) Total ventricular volume ( 21116278)
Interacting Genes		15 interacting genes: BAG6 C1R C1S ELANE ENO1 F2 MASP1 MASP2 NR4A1 PLAT PLG SELE SELP SLC30A2 SRPK2	10 interacting genes: AP1M1 CD24 EZR FUT4 GP1BA SELPLG SERPING1 SNX17 SNX27 VCAN
Entrez ID		710	6403
HPRD ID		06033	01433
Ensembl ID		ENSG00000149131	ENSG00000174175
Uniprot IDs		E9KL26 P05155	A0A024R8Y9 P16109 Q5R341 Q6NUL9
PDB IDs		1M6Q 2OAY 5DU3 5DUQ	1FSB 1G1Q 1G1R 1G1S 1HES 1KJD
Enriched GO Terms of Interacting Partners?
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