SELP and SNX27

Data Source:
BioGRID (pull down)

		SELP	SNX27
Description		selectin P	sorting nexin 27
Image
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Platelet Dense Granule Membrane Platelet Alpha Granule Membrane	Immunological Synapse Nucleoplasm Endosome Early Endosome Cytosol Retromer Complex Early Endosome Membrane WASH Complex
	Molecular Function	Lipopolysaccharide Binding Calcium Ion Binding Protein Binding Heparin Binding Sialic Acid Binding Fucose Binding Glycosphingolipid Binding Calcium-dependent Protein Binding Oligosaccharide Binding	Protein Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding
	Biological Process	Platelet Degranulation Positive Regulation Of Leukocyte Migration Inflammatory Response Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Positive Regulation Of Platelet Activation Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Calcium-dependent Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Response To Lipopolysaccharide Regulation Of Integrin Activation Calcium-mediated Signaling Using Intracellular Calcium Source Defense Response To Gram-negative Bacterium Leukocyte Migration Leukocyte Tethering Or Rolling Positive Regulation Of Leukocyte Tethering Or Rolling	Establishment Of Natural Killer Cell Polarity Intracellular Protein Transport Signal Transduction Endosome To Lysosome Transport Endosomal Transport Retrograde Transport, Endosome To Plasma Membrane
Pathways		Platelet degranulation Cell surface interactions at the vascular wall
Drugs		Heparin N-acetyl-alpha-neuraminic acid Dalteparin Nadroparin Crizanlizumab
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Blood protein levels ( 30072576 29875488 28240269) Hippocampal atrophy ( 22745009) Inflammatory bowel disease ( 26192919) L-selectin levels ( 25576479) Late-onset Alzheimer's disease ( 27770636) Optic disc size ( 31809533) Soluble levels of adhesion molecules ( 20167578) Total ventricular volume ( 21116278)	Body mass index ( 26426971)
Interacting Genes		10 interacting genes: AP1M1 CD24 EZR FUT4 GP1BA SELPLG SERPING1 SNX17 SNX27 VCAN	9 interacting genes: AKT2 APP DGKZ HLCS PNPLA3 PTEN RPS6KA1 SELP SUMO2
Entrez ID		6403	81609
HPRD ID		01433	11591
Ensembl ID		ENSG00000174175	ENSG00000143376
Uniprot IDs		A0A024R8Y9 P16109 Q5R341 Q6NUL9	A0A2R8Y8A7 Q96L92
PDB IDs		1FSB 1G1Q 1G1R 1G1S 1HES 1KJD	4HAS 5ZN9 6SAK
Enriched GO Terms of Interacting Partners?
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