DYNLT1 and DVL1

Data Source:
HPRD (two hybrid)

		DYNLT1	DVL1
Description		dynein light chain Tctex-type 1	dishevelled segment polarity protein 1
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GO Annotations	Cellular Component	Extracellular Region Mitochondrion Golgi Apparatus Spindle Cytoplasmic Dynein Complex Cytoplasmic Microtubule Lamellipodium Secretory Granule Lumen Neuronal Cell Body Host Cell Axonal Growth Cone Secretory Vesicle Ficolin-1-rich Granule Lumen	Cytosol Microtubule Postsynaptic Density Lateral Plasma Membrane Clathrin-coated Vesicle Growth Cone Cytoplasmic Vesicle Neuron Projection Neuronal Cell Body Dendritic Spine Synapse Schaffer Collateral - CA1 Synapse Presynapse Glutamatergic Synapse Wnt Signalosome
	Molecular Function	Motor Activity Protein Binding Protein C-terminus Binding Identical Protein Binding	Molecular_function Frizzled Binding Protein Binding Beta-catenin Binding Enzyme Binding Protein Kinase Binding Identical Protein Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Neuron Projection Development Dendrite Development Intracellular Transport Of Viral Protein In Host Cell Positive Regulation Of Rac Protein Signal Transduction Negative Regulation Of Mitochondrial Membrane Permeability Regulation Of GTPase Activity Neutrophil Degranulation Viral Entry Into Host Cell Neuron Projection Morphogenesis Negative Regulation Of Neurogenesis Cell Division Regulation Of Cytoskeleton Organization Negative Regulation Of Cell Death Axon Development Microtubule-dependent Intracellular Transport Of Viral Material Towards Nucleus	Regulation Of Neurotransmitter Levels Positive Regulation Of Protein Phosphorylation Regulation Of Transcription, DNA-templated Negative Regulation Of Protein Kinase Activity Neurotransmitter Secretion Axon Guidance Heart Development Neuromuscular Junction Development Positive Regulation Of Neuron Projection Development Neural Tube Development Convergent Extension Involved In Neural Plate Elongation Cytoplasmic Microtubule Organization Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Localization To Nucleus Social Behavior Protein Localization To Microtubule Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Receptor Clustering Positive Regulation Of Transcription By RNA Polymerase II Collateral Sprouting Axon Extension Dendrite Morphogenesis Synapse Organization Protein Stabilization Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Prepulse Inhibition Dendritic Spine Morphogenesis Skeletal Muscle Acetylcholine-gated Channel Clustering Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Presynapse Assembly Positive Regulation Of Neuron Projection Arborization Regulation Of Cellular Protein Localization Beta-catenin Destruction Complex Disassembly Positive Regulation Of Protein Localization To Presynapse Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Excitatory Postsynaptic Potential
Pathways		Neutrophil degranulation	TCF dependent signaling in response to WNT WNT mediated activation of DVL PCP/CE pathway PCP/CE pathway Degradation of DVL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Negative regulation of TCF-dependent signaling by DVL-interacting proteins RHO GTPases Activate Formins WNT5:FZD7-mediated leishmania damping WNT5:FZD7-mediated leishmania damping
Drugs
Diseases
GWAS			Inflammatory bowel disease ( 28067908) Nicotine dependence ( 32281736) Ulcerative colitis ( 28067908)
Interacting Genes		50 interacting genes: ACOX2 ACTN1 APP ARID4B BAG3 BMPR2 CCDC68 DDX54 DHX33 DNAJA2 DOC2A DOC2B DVL1 DVL2 DYNC1I1 DYNC1I2 DYNLT2B DYNLT3 FXR2 HAVCR1 HSPB7 HSPB9 ILF2 KIF2A KLK15 LNX1 NHSL2 NTAQ1 NUP153 NUP62 OLFM3 PELO PITX2 PSMA1 PTGES3L-AARSD1 PTH2R PVR RAD21 RBM14 RRAGA SDCBP SIRPA SVIL TCEANC TROAP TUBA3C TXN UXT VDAC1 XRN2	43 interacting genes: ANXA7 ARRB1 ATN1 AXIN1 BAG3 BRD7 BUB1 CCDC88C CSNK1D CSNK1E CSNK2A1 CTNNB1 CXXC4 DAAM1 DAB2 DVL3 DYNLT1 EPS8 FBXW7 FRAT1 HDHD2 HECW1 KLHL12 LRRK2 MLH3 MSH2 NCK2 NEDD4 PPM1A PSMA3 RAC1 RB1 SIPA1 SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 SMYD1 TRIM69 USP13 VANGL1 VANGL2
Entrez ID		6993	1855
HPRD ID		15987	03220
Ensembl ID		ENSG00000146425	ENSG00000107404
Uniprot IDs		P63172	O14640
PDB IDs		5JPW	6TTK
Enriched GO Terms of Interacting Partners?
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