DVL1 and SIPA1

Data Source:
BioGRID (two hybrid)

		DVL1	SIPA1
Description		dishevelled segment polarity protein 1	signal-induced proliferation-associated 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Microtubule Postsynaptic Density Lateral Plasma Membrane Clathrin-coated Vesicle Growth Cone Cytoplasmic Vesicle Neuron Projection Neuronal Cell Body Dendritic Spine Synapse Schaffer Collateral - CA1 Synapse Presynapse Glutamatergic Synapse Wnt Signalosome	Nucleus Cytoplasm Cytosol Membrane Transport Vesicle Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Molecular_function Frizzled Binding Protein Binding Beta-catenin Binding Enzyme Binding Protein Kinase Binding Identical Protein Binding	GTPase Activator Activity Protein Binding Protein C-terminus Binding
	Biological Process	Regulation Of Neurotransmitter Levels Positive Regulation Of Protein Phosphorylation Regulation Of Transcription, DNA-templated Negative Regulation Of Protein Kinase Activity Neurotransmitter Secretion Axon Guidance Heart Development Neuromuscular Junction Development Positive Regulation Of Neuron Projection Development Neural Tube Development Convergent Extension Involved In Neural Plate Elongation Cytoplasmic Microtubule Organization Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Localization To Nucleus Social Behavior Protein Localization To Microtubule Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Receptor Clustering Positive Regulation Of Transcription By RNA Polymerase II Collateral Sprouting Axon Extension Dendrite Morphogenesis Synapse Organization Protein Stabilization Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Prepulse Inhibition Dendritic Spine Morphogenesis Skeletal Muscle Acetylcholine-gated Channel Clustering Negative Regulation Of Canonical Wnt Signaling Pathway Cochlea Morphogenesis Planar Cell Polarity Pathway Involved In Neural Tube Closure Presynapse Assembly Positive Regulation Of Neuron Projection Arborization Regulation Of Cellular Protein Localization Beta-catenin Destruction Complex Disassembly Positive Regulation Of Protein Localization To Presynapse Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Excitatory Postsynaptic Potential	Cytoskeleton Organization Negative Regulation Of Cell Adhesion Signal Transduction Negative Regulation Of Cell Growth Intracellular Signal Transduction Cellular Response To Water Deprivation Negative Regulation Of Cell Cycle Regulation Of Small GTPase Mediated Signal Transduction Activation Of GTPase Activity
Pathways		TCF dependent signaling in response to WNT WNT mediated activation of DVL PCP/CE pathway PCP/CE pathway Degradation of DVL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Negative regulation of TCF-dependent signaling by DVL-interacting proteins RHO GTPases Activate Formins WNT5:FZD7-mediated leishmania damping WNT5:FZD7-mediated leishmania damping	Rap1 signalling
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 28067908) Nicotine dependence ( 32281736) Ulcerative colitis ( 28067908)	Acne (severe) ( 24927181) Asthma ( 31619474) Coronary artery disease ( 33020668) Diastolic blood pressure ( 27841878) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) HDL cholesterol ( 30275531) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Metabolic syndrome ( 31589552) Platelet count ( 27863252) Pulse pressure ( 30578418) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Systolic blood pressure ( 27841878 27618452 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
Interacting Genes		43 interacting genes: ANXA7 ARRB1 ATN1 AXIN1 BAG3 BRD7 BUB1 CCDC88C CSNK1D CSNK1E CSNK2A1 CTNNB1 CXXC4 DAAM1 DAB2 DVL3 DYNLT1 EPS8 FBXW7 FRAT1 HDHD2 HECW1 KLHL12 LRRK2 MLH3 MSH2 NCK2 NEDD4 PPM1A PSMA3 RAC1 RB1 SIPA1 SMAD1 SMAD2 SMAD3 SMAD4 SMAD7 SMYD1 TRIM69 USP13 VANGL1 VANGL2	3 interacting genes: CDKN1A COP1 DVL1
Entrez ID		1855	6494
HPRD ID		03220	03713
Ensembl ID		ENSG00000107404	ENSG00000213445
Uniprot IDs		O14640	Q96FS4
PDB IDs		6TTK
Enriched GO Terms of Interacting Partners?
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