TACC1 and YEATS4

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo, two hybrid)

		TACC1	YEATS4
Description		transforming acidic coiled-coil containing protein 1	YEATS domain containing 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Microtubule Organizing Center Cytosol Membrane Midbody	Nucleus Nucleoplasm Nuclear Matrix Nuclear Membrane NuA4 Histone Acetyltransferase Complex
	Molecular Function	Protein Binding Nuclear Receptor Binding Estrogen Receptor Binding Nuclear Receptor Coactivator Activity Glucocorticoid Receptor Binding Retinoic Acid Receptor Binding Peroxisome Proliferator Activated Receptor Binding Retinoid X Receptor Binding Thyroid Hormone Receptor Binding	Structural Constituent Of Cytoskeleton Protein Binding Protein C-terminus Binding Lysine-acetylated Histone Binding Modification-dependent Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Spindle Organization Cell Population Proliferation Cerebral Cortex Development Positive Regulation Of Transcription, DNA-templated Cell Division	Mitotic Cell Cycle Cytoskeleton Organization Regulation Of Growth Histone H4 Acetylation Histone H2A Acetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II
Pathways			HATs acetylate histones Activation of the TFAP2 (AP-2) family of transcription factors
Drugs
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Chronic mountain sickness ( 31417607) Midgestational circulating levels of PBDEs ( 28235828)	Complete remission in asthma ( 29786918) Depressive symptoms x independent stressful life events interaction (1df test) ( 30718454) Height ( 31562340 18391951) Metabolite levels ( 23823483) Response to antidepressants (symptom remission) ( 29160301) Response to diuretic therapy ( 18591461) Response to SSRI in MDD or conscientiouness ( 29559929) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		20 interacting genes: AURKA AURKB BTRC ERCC4 FAM50B HTT ITSN2 KAT2A KDM1A LSM7 MEMO1 SH2D4A SNRPG STX5 TDRD7 THAP12 THRA YEATS4 ZFHX3 ZNF48	17 interacting genes: ANKK1 CEP162 FRMD4A GTF2F2 H3C1 MLLT10 MRGBP MYCN NUMA1 PFDN1 RNF8 SMARCB1 TACC1 TACC2 TFAP2B TPM1 TRIM54
Entrez ID		6867	8089
HPRD ID		10391	03666
Ensembl ID		ENSG00000147526	ENSG00000127337
Uniprot IDs		E7EVI4 O75410 Q5HYH0	F8W0J4 O95619
PDB IDs			5VNA 5VNB 5XTZ 5Y8V
Enriched GO Terms of Interacting Partners?
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