SSRP1 and SREK1

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		SSRP1	SREK1
Description		structure specific recognition protein 1	splicing regulatory glutamic acid and lysine rich protein 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus FACT Complex	Nucleoplasm Spliceosomal Complex Nuclear Speck
	Molecular Function	DNA Binding RNA Binding Protein Binding Nucleosome Binding Histone Binding	RNA Binding Protein Binding
	Biological Process	DNA Replication DNA Repair Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Viral Process Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Chromatin Organization	MRNA Processing RNA Splicing
Pathways		Formation of RNA Pol II elongation complex Formation of HIV elongation complex in the absence of HIV Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes Regulation of TP53 Activity through Phosphorylation RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS			Logical memory (delayed recall) in mild cognitive impairment ( 29274321) Systolic blood pressure ( 30224653)
Interacting Genes		22 interacting genes: AURKA CHD1 CHMP1B CSNK2A1 DHX9 EXOSC10 H2AC20 H2AX H2BC21 H3-3A MCM4 MYCBP NEK9 PTEN RAN ROBO2 SPI1 SREK1 SRF SUMO2 SUPT16H UBE2I	60 interacting genes: ARL6IP4 CD8A CSNK2A1 DDX17 DDX39B DDX3X DGKA DGKD EFTUD2 ELAVL1 GPRASP2 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPC HNRNPD HNRNPH1 HNRNPK HNRNPU ILF2 MDM2 NCL NPM1 PABPC1 PABPC4 PARP1 PIN1 PRPF40A RACK1 RBM10 RBM39 RBMX SAFB SF3A3 SF3B3 SFPQ SH3GLB2 SNRPD1 SNRPD3 SRPK1 SRPK2 SRPK3 SRSF1 SRSF10 SRSF11 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF8 SSRP1 SUPT16H TARBP1 THRAP3 TRA2B TXLNA YBX1 ZRANB2
Entrez ID		6749	140890
HPRD ID		05061	18043
Ensembl ID		ENSG00000149136	ENSG00000153914
Uniprot IDs		A0A024R4Z6 Q08945	Q8WXA9
PDB IDs		4IFS 5UMR 5UMS 5VWE 6L1E 6L1R 6L34 6UPK 6UPL
Enriched GO Terms of Interacting Partners?
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