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SREK1 and NPM1
Data Source:
HPRD
(in vivo, two hybrid, in vitro)
SREK1
NPM1
Description
splicing regulatory glutamic acid and lysine rich protein 1
nucleophosmin 1
Image
No pdb structure
GO Annotations
Cellular Component
Nucleoplasm
Spliceosomal Complex
Nuclear Speck
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Centrosome
Cytosol
Focal Adhesion
Membrane
Spindle Pole Centrosome
Protein-containing Complex
Protein-DNA Complex
Ribonucleoprotein Complex
Molecular Function
RNA Binding
Protein Binding
Core Promoter Sequence-specific DNA Binding
Chromatin Binding
Transcription Coactivator Activity
RNA Binding
Protein Kinase Inhibitor Activity
Protein Binding
Transcription Factor Binding
Protein Kinase Binding
Tat Protein Binding
Activating Transcription Factor Binding
Histone Binding
Protein Homodimerization Activity
Ribosomal Large Subunit Binding
Ribosomal Small Subunit Binding
NF-kappaB Binding
Unfolded Protein Binding
Biological Process
MRNA Processing
RNA Splicing
Ribosomal Large Subunit Export From Nucleus
Ribosomal Small Subunit Export From Nucleus
DNA Repair
Nucleosome Assembly
Chromatin Remodeling
Regulation Of Transcription By RNA Polymerase II
RRNA Export From Nucleus
Intracellular Protein Transport
Nucleocytoplasmic Transport
Centrosome Cycle
Signal Transduction
Cell Aging
Protein Localization
Positive Regulation Of Cell Population Proliferation
Negative Regulation Of Cell Population Proliferation
Regulation Of Centrosome Duplication
Negative Regulation Of Centrosome Duplication
Viral Process
Regulation Of Endodeoxyribonuclease Activity
CENP-A Containing Nucleosome Assembly
Cellular Response To UV
Ribosome Assembly
Ribosomal Large Subunit Biogenesis
Ribosomal Small Subunit Biogenesis
Negative Regulation Of Apoptotic Process
Negative Regulation Of Protein Kinase Activity By Regulation Of Protein Phosphorylation
Positive Regulation Of Translation
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Centriole Replication
Positive Regulation Of NF-kappaB Transcription Factor Activity
Regulation Of Endoribonuclease Activity
Regulation Of EIF2 Alpha Phosphorylation By DsRNA
Regulation Of MRNA Stability Involved In Cellular Response To UV
Positive Regulation Of Cell Cycle G2/M Phase Transition
Pathways
Nuclear import of Rev protein
Nuclear import of Rev protein
SUMOylation of transcription cofactors
Deposition of new CENPA-containing nucleosomes at the centromere
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation
Drugs
Artenimol
Diseases
GWAS
Logical memory (delayed recall) in mild cognitive impairment (
29274321
)
Systolic blood pressure (
30224653
)
Brain morphology (MOSTest) (
32665545
)
Height (
28552196
)
Subcortical volume (MOSTest) (
32665545
)
Interacting Genes
60 interacting genes:
ARL6IP4
CD8A
CSNK2A1
DDX17
DDX39B
DDX3X
DGKA
DGKD
EFTUD2
ELAVL1
GPRASP2
HNRNPA1
HNRNPA2B1
HNRNPA3
HNRNPC
HNRNPD
HNRNPH1
HNRNPK
HNRNPU
ILF2
MDM2
NCL
NPM1
PABPC1
PABPC4
PARP1
PIN1
PRPF40A
RACK1
RBM10
RBM39
RBMX
SAFB
SF3A3
SF3B3
SFPQ
SH3GLB2
SNRPD1
SNRPD3
SRPK1
SRPK2
SRPK3
SRSF1
SRSF10
SRSF11
SRSF2
SRSF3
SRSF4
SRSF5
SRSF6
SRSF7
SRSF8
SSRP1
SUPT16H
TARBP1
THRAP3
TRA2B
TXLNA
YBX1
ZRANB2
62 interacting genes:
ABCC1
ACY1
ALK
APP
ARF1
CACYBP
CD24
CDK1
CDK2
CDKN2A
CDT1
CENPW
CLK1
COX8A
CSNK2A1
DUX4
EIF2AK2
ELF4
EP300
ERG
ESR1
FBXW7
GADD45A
GNAI2
GNL3
GRB2
GZMM
H2AC20
H2BC21
H3-4
HAND2
HMGA1
HMGA2
HOXA7
IRF1
IRS1
LINC01554
MDM2
NCL
NOP2
NPM2
PADI4
PARP1
PLCG1
PLCG2
PLK1
PSMC4
RELA
RPGR
SENP3
SHC1
SP1
SREK1
SUMO2
TCERG1
TFAP2A
TP53
TRIM28
UBC
UQCRH
XPO1
YY1
Entrez ID
140890
4869
HPRD ID
18043
01246
Ensembl ID
ENSG00000153914
ENSG00000181163
Uniprot IDs
Q8WXA9
A0A0S2Z491
A0A0S2Z4G7
A0A140VJQ2
P06748
PDB IDs
2LLH
2P1B
2VXD
5EHD
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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