SREK1 and DGKA

Data Source:
HPRD (two hybrid)

		SREK1	DGKA
Description		splicing regulatory glutamic acid and lysine rich protein 1	diacylglycerol kinase alpha
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Spliceosomal Complex Nuclear Speck	Cytosol Plasma Membrane Membrane
	Molecular Function	RNA Binding Protein Binding	NAD+ Kinase Activity Diacylglycerol Kinase Activity Calcium Ion Binding ATP Binding Phospholipid Binding Lipid Binding Kinase Activity
	Biological Process	MRNA Processing RNA Splicing	Phosphatidic Acid Biosynthetic Process Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Platelet Activation Intracellular Signal Transduction Diacylglycerol Metabolic Process Glycerolipid Metabolic Process Lipid Phosphorylation
Pathways			Effects of PIP2 hydrolysis
Drugs			Vitamin E alpha-Tocopherol succinate
Diseases
GWAS		Logical memory (delayed recall) in mild cognitive impairment ( 29274321) Systolic blood pressure ( 30224653)	Anorexia nervosa ( 28494655) Refractive error ( 32231278) Vitiligo ( 22951725)
Interacting Genes		60 interacting genes: ARL6IP4 CD8A CSNK2A1 DDX17 DDX39B DDX3X DGKA DGKD EFTUD2 ELAVL1 GPRASP2 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPC HNRNPD HNRNPH1 HNRNPK HNRNPU ILF2 MDM2 NCL NPM1 PABPC1 PABPC4 PARP1 PIN1 PRPF40A RACK1 RBM10 RBM39 RBMX SAFB SF3A3 SF3B3 SFPQ SH3GLB2 SNRPD1 SNRPD3 SRPK1 SRPK2 SRPK3 SRSF1 SRSF10 SRSF11 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF8 SSRP1 SUPT16H TARBP1 THRAP3 TRA2B TXLNA YBX1 ZRANB2	3 interacting genes: IL21 SRC SREK1
Entrez ID		140890	1606
HPRD ID		18043	00517
Ensembl ID		ENSG00000153914	ENSG00000065357
Uniprot IDs		Q8WXA9	A0A024RB23 P23743
PDB IDs			1TUZ 6IIE
Enriched GO Terms of Interacting Partners?
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