SREK1 and DGKD

Data Source:
BioGRID (two hybrid)

		SREK1	DGKD
Description		splicing regulatory glutamic acid and lysine rich protein 1	diacylglycerol kinase delta
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Spliceosomal Complex Nuclear Speck	Nucleus Cytoplasm Cytosol Plasma Membrane Clathrin-coated Pit
	Molecular Function	RNA Binding Protein Binding	NAD+ Kinase Activity Diacylglycerol Kinase Activity Protein Binding ATP Binding Kinase Binding Diacylglycerol Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	MRNA Processing RNA Splicing	Phosphatidic Acid Biosynthetic Process Endocytosis Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Multicellular Organism Development Response To Organic Substance Protein Transport Second-messenger-mediated Signaling Platelet Activation Intracellular Signal Transduction Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Diacylglycerol Metabolic Process Lipid Phosphorylation Negative Regulation Of Protein Kinase C Signaling Positive Regulation Of Clathrin-dependent Endocytosis
Pathways			Effects of PIP2 hydrolysis
Drugs			Phosphatidyl serine alpha-Tocopherol succinate
Diseases
GWAS		Logical memory (delayed recall) in mild cognitive impairment ( 29274321) Systolic blood pressure ( 30224653)	Bilirubin levels ( 20639394 32084209) Calcium levels ( 24068962 29403010 20705733) Crohn's disease ( 22412388) Glaucoma (primary open-angle) ( 29891935) Kidney stones ( 31729369) Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494 27863252) Total body bone mineral density ( 29304378) Type 2 diabetes ( 32499647 30718926) Urinary calcium excretion ( 31993563)
Interacting Genes		60 interacting genes: ARL6IP4 CD8A CSNK2A1 DDX17 DDX39B DDX3X DGKA DGKD EFTUD2 ELAVL1 GPRASP2 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPC HNRNPD HNRNPH1 HNRNPK HNRNPU ILF2 MDM2 NCL NPM1 PABPC1 PABPC4 PARP1 PIN1 PRPF40A RACK1 RBM10 RBM39 RBMX SAFB SF3A3 SF3B3 SFPQ SH3GLB2 SNRPD1 SNRPD3 SRPK1 SRPK2 SRPK3 SRSF1 SRSF10 SRSF11 SRSF2 SRSF3 SRSF4 SRSF5 SRSF6 SRSF7 SRSF8 SSRP1 SUPT16H TARBP1 THRAP3 TRA2B TXLNA YBX1 ZRANB2	8 interacting genes: DGKH DYSF HAX1 IGSF21 MYH2 PRKCA SREK1 TNFRSF14
Entrez ID		140890	8527
HPRD ID		18043	03492
Ensembl ID		ENSG00000153914	ENSG00000077044
Uniprot IDs		Q8WXA9	A0A024R495 Q16760
PDB IDs			1R79 3BQ7
Enriched GO Terms of Interacting Partners?
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