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SREK1 and HNRNPU
Data Source:
HPRD
(two hybrid, in vivo, in vitro)
SREK1
HNRNPU
Description
splicing regulatory glutamic acid and lysine rich protein 1
heterogeneous nuclear ribonucleoprotein U
Image
No pdb structure
GO Annotations
Cellular Component
Nucleoplasm
Spliceosomal Complex
Nuclear Speck
Nuclear Chromosome
Kinetochore
Condensed Chromosome Kinetochore
Spindle Pole
Nucleus
Nucleoplasm
Telomerase Holoenzyme Complex
Centrosome
Cell Surface
Membrane
Nuclear Matrix
Nuclear Speck
Midbody
Dendrite Cytoplasm
Protein-containing Complex
Cytoplasmic Ribonucleoprotein Granule
CRD-mediated MRNA Stability Complex
Catalytic Step 2 Spliceosome
Mitotic Spindle
RNA Polymerase II Transcription Regulator Complex
Inactive Sex Chromosome
Mitotic Spindle Midzone
Mitotic Spindle Microtubule
Ribonucleoprotein Complex
Molecular Function
RNA Binding
Protein Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Complex Binding
TFIIH-class Transcription Factor Complex Binding
DNA Binding
Chromatin Binding
Double-stranded DNA Binding
Single-stranded DNA Binding
Transcription Corepressor Activity
RNA Binding
Double-stranded RNA Binding
Single-stranded RNA Binding
MRNA 3'-UTR Binding
Actin Binding
Protein Binding
ATP Binding
Poly(A) Binding
SnRNA Binding
Poly(C) RNA Binding
Chromatin DNA Binding
Poly(G) Binding
Pre-mRNA Binding
Identical Protein Binding
Ribonucleoprotein Complex Binding
Protein-containing Complex Binding
Telomerase RNA Binding
RNA Polymerase II C-terminal Domain Binding
Sequence-specific Double-stranded DNA Binding
Promoter-specific Chromatin Binding
Biological Process
MRNA Processing
RNA Splicing
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Alternative MRNA Splicing, Via Spliceosome
MRNA Splicing, Via Spliceosome
Osteoblast Differentiation
Chromatin Organization
RNA Processing
Cell Cycle
Regulation Of Mitotic Cell Cycle
Dosage Compensation By Inactivation Of X Chromosome
Viral Process
RNA Metabolic Process
Negative Regulation Of Telomere Maintenance Via Telomerase
Circadian Regulation Of Gene Expression
Negative Regulation Of Kinase Activity
Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter
Positive Regulation Of Transcription By RNA Polymerase II
MRNA Stabilization
Cell Division
Maintenance Of Protein Location In Nucleus
Cardiac Muscle Cell Development
CRD-mediated MRNA Stabilization
Cellular Response To Glucocorticoid Stimulus
Positive Regulation Of Brown Fat Cell Differentiation
Dendritic Transport Of Messenger Ribonucleoprotein Complex
Regulation Of Mitotic Spindle Assembly
Regulation Of Chromatin Organization
Positive Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore
Protein Localization To Spindle Microtubule
RNA Localization To Chromatin
Cellular Response To Leukemia Inhibitory Factor
Adaptive Thermogenesis
Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity
Positive Regulation Of Stem Cell Proliferation
Negative Regulation Of Stem Cell Differentiation
Pathways
mRNA Splicing - Major Pathway
Processing of Capped Intron-Containing Pre-mRNA
Drugs
Diseases
GWAS
Logical memory (delayed recall) in mild cognitive impairment (
29274321
)
Systolic blood pressure (
30224653
)
Interacting Genes
60 interacting genes:
ARL6IP4
CD8A
CSNK2A1
DDX17
DDX39B
DDX3X
DGKA
DGKD
EFTUD2
ELAVL1
GPRASP2
HNRNPA1
HNRNPA2B1
HNRNPA3
HNRNPC
HNRNPD
HNRNPH1
HNRNPK
HNRNPU
ILF2
MDM2
NCL
NPM1
PABPC1
PABPC4
PARP1
PIN1
PRPF40A
RACK1
RBM10
RBM39
RBMX
SAFB
SF3A3
SF3B3
SFPQ
SH3GLB2
SNRPD1
SNRPD3
SRPK1
SRPK2
SRPK3
SRSF1
SRSF10
SRSF11
SRSF2
SRSF3
SRSF4
SRSF5
SRSF6
SRSF7
SRSF8
SSRP1
SUPT16H
TARBP1
THRAP3
TRA2B
TXLNA
YBX1
ZRANB2
38 interacting genes:
ACTB
BTRC
CASP3
CD5
CDKN2A
CR2
DUX4
ELL
EP300
ERG
GRIN1
GRIN2D
GTF2H1
HNRNPH3
HSPB1
IL7R
KAT2B
NDN
NDRG1
NEDD4
NR3C1
PIN1
POLR2A
POU3F4
PRMT1
PRPF40A
PTPN11
RBPMS2
SMN1
SREK1
STAU1
SUMO2
SYK
TCERG1
UBE2I
WBP4
YAP1
ZNF689
Entrez ID
140890
3192
HPRD ID
18043
04185
Ensembl ID
ENSG00000153914
ENSG00000153187
Uniprot IDs
Q8WXA9
Q00839
Q96BA7
PDB IDs
1ZRJ
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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