SREBF2 and LINC00839

Data Source:
BioGRID (unspecified method)

		SREBF2	LINC00839
Description		sterol regulatory element binding transcription factor 2	long intergenic non-protein coding RNA 839
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Chromatin Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane SREBP-SCAP-Insig Complex Intracellular Membrane-bounded Organelle
	Molecular Function	C-8 Sterol Isomerase Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Protein C-terminus Binding Protein Dimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process Cholesterol Metabolic Process Regulation Of Notch Signaling Pathway Cellular Response To Starvation Positive Regulation Of Cholesterol Storage SREBP Signaling Pathway Cholesterol Homeostasis Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Low-density Lipoprotein Particle Stimulus Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Cholesterol Efflux Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) Regulation of cholesterol biosynthesis by SREBP (SREBF) PPARA activates gene expression Activation of gene expression by SREBF (SREBP) Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Birth weight ( 31043758 27680694) General cognitive ability ( 29844566) Processed meat consumption ( 32066663) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)
Interacting Genes		50 interacting genes: ABLIM1 ABLIM2 ARHGEF1 ARRB1 ATF7IP ATXN1 AURKA CASP3 CASP8AP2 COPS5 CREB1 CREBBP EGR1 EP300 FHL2 FHL3 GOLGB1 HNF4A HSPA5 INSIG1 INSIG2 ITGB4 KLF13 KPNB1 LINC00839 LZTR1 MAPK1 MAPK3 MRPS6 MTNR1B NAE1 NFYA NFYC OS9 PIAS1 PIAS2 PIAS3 PSMD4 RAB11B SCAP SLC4A4 SMAD3 SP1 SPTBN1 SUMO1 TTC1 UBE2I ZDHHC17 ZMYM2 ZYX	82 interacting genes: ADAMTS15 AKAP13 ALDH16A1 APOL3 BFSP1 CALM1 CC2D1B CCDC168 CCDC93 CDC16 CEP192 CEP295NL CHPF CIZ1 CLGN CLPTM1 COPB1 DNAH10 DPEP3 EFL1 EID2 EMX1 FAAP100 FAM13B FBXL5 HAPLN4 IQCN IRX4 JAKMIP2 KLK14 KRT1 KRT6B L1CAM MEX3A MEX3B MEX3C MEX3D MICAL2 MYO7A NDUFA2 NOC4L NOTCH3 NVL OS9 P4HB PABPN1 PALM3 PARP6 PHACTR1 PKD1L2 PLOD3 PNPLA3 POMT2 PRSS1 PRSS3 PTBP1 PTEN PTPRA QSOX2 RAPGEF6 RIF1 RPLP2 RPTOR RYR2 SEMA4D SEPTIN12 SEPTIN9 SERHL2 SLC7A14 SOWAHB SREBF2 SYNE1 SYNE3 TAS1R3 TCF24 TMC4 TRO UBE2S VANGL1 YAP1 YIPF1 ZFPL1
Entrez ID		6721	84856
HPRD ID		02726	17516
Ensembl ID		ENSG00000198911	ENSG00000185904
Uniprot IDs		A0A024R1Q0 Q12772
PDB IDs		1UKL
Enriched GO Terms of Interacting Partners?
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