SREBF2 and ATF7IP

Data Source:
BioGRID (two hybrid)

		SREBF2	ATF7IP
Description		sterol regulatory element binding transcription factor 2	activating transcription factor 7 interacting protein
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GO Annotations	Cellular Component	Golgi Membrane Chromatin Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane SREBP-SCAP-Insig Complex Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Transcription Regulator Complex Cytosol Nuclear Body
	Molecular Function	C-8 Sterol Isomerase Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Protein C-terminus Binding Protein Dimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding	Transcription Corepressor Activity Protein Binding ATPase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process Cholesterol Metabolic Process Regulation Of Notch Signaling Pathway Cellular Response To Starvation Positive Regulation Of Cholesterol Storage SREBP Signaling Pathway Cholesterol Homeostasis Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Low-density Lipoprotein Particle Stimulus Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Cholesterol Efflux Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Protein Targeting To Mitochondrion	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation Viral Process Regulation Of Protein Stability Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Protein Stabilization Positive Regulation Of DNA Methylation-dependent Heterochromatin Assembly
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) Regulation of cholesterol biosynthesis by SREBP (SREBF) PPARA activates gene expression Activation of gene expression by SREBF (SREBP) Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation EGR2 and SOX10-mediated initiation of Schwann cell myelination	PKMTs methylate histone lysines
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Birth weight ( 31043758 27680694) General cognitive ability ( 29844566) Processed meat consumption ( 32066663) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)	Breast cancer ( 24143190) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Height ( 31562340) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Leukocyte telomere length ( 32109421) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Prostate-specific antigen levels ( 23359319) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 28604728 28604732 23666240)
Interacting Genes		50 interacting genes: ABLIM1 ABLIM2 ARHGEF1 ARRB1 ATF7IP ATXN1 AURKA CASP3 CASP8AP2 COPS5 CREB1 CREBBP EGR1 EP300 FHL2 FHL3 GOLGB1 HNF4A HSPA5 INSIG1 INSIG2 ITGB4 KLF13 KPNB1 LINC00839 LZTR1 MAPK1 MAPK3 MRPS6 MTNR1B NAE1 NFYA NFYC OS9 PIAS1 PIAS2 PIAS3 PSMD4 RAB11B SCAP SLC4A4 SMAD3 SP1 SPTBN1 SUMO1 TTC1 UBE2I ZDHHC17 ZMYM2 ZYX	70 interacting genes: A2M ACTB ACTG1 AP1B1 CADM1 CEP250 COL4A2 CREB1 CREBBP CSPG4 DISC1 DMTF1 DNM2 EHMT2 EPG5 FLNB FLT4 GMEB1 GTF2E2 GTF2F1 GTF2H1 HEYL HLA-B HSPG2 KIF13A KRT7 LAMA4 LAMA5 LAMC1 LUC7L2 MACF1 MBD1 MCAM MED4 MRI1 NOMO1 NPR1 PAPPA PAPPA2 PCDH1 PEX6 PIAS3 PKD1 PLEKHB2 POLR2C POLR2D POLR2G PRSS8 PSG3 QRICH1 RPS3A RRBP1 SENP3 SETDB1 SLC12A4 SMAD4 SP1 SPTBN1 SREBF2 STBD1 STRN SUMO2 SUSD1 SVEP1 TRIP12 TTC3 UBE2I ZBTB6 ZNF350 ZNF518A
Entrez ID		6721	55729
HPRD ID		02726	09811
Ensembl ID		ENSG00000198911	ENSG00000171681
Uniprot IDs		A0A024R1Q0 Q12772	A0A024RAY1 B3KNI7 B3KQF8 Q6VMQ6
PDB IDs		1UKL	2RPQ
Enriched GO Terms of Interacting Partners?
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