SREBF2 and OS9

Data Source:
BioGRID (two hybrid)

		SREBF2	OS9
Description		sterol regulatory element binding transcription factor 2	OS9 endoplasmic reticulum lectin
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GO Annotations	Cellular Component	Golgi Membrane Chromatin Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane SREBP-SCAP-Insig Complex Intracellular Membrane-bounded Organelle	Hrd1p Ubiquitin Ligase Complex Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Endoplasmic Reticulum Quality Control Compartment
	Molecular Function	C-8 Sterol Isomerase Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Protein C-terminus Binding Protein Dimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding	Protease Binding Protein Binding Carbohydrate Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process Cholesterol Metabolic Process Regulation Of Notch Signaling Pathway Cellular Response To Starvation Positive Regulation Of Cholesterol Storage SREBP Signaling Pathway Cholesterol Homeostasis Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Low-density Lipoprotein Particle Stimulus Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Cholesterol Efflux Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Protein Targeting To Mitochondrion	Ubiquitin-dependent Protein Catabolic Process Protein Targeting Protein Retention In ER Lumen Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol Response To Endoplasmic Reticulum Stress Transmembrane Transport Negative Regulation Of Retrograde Protein Transport, ER To Cytosol Endoplasmic Reticulum Mannose Trimming
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) Regulation of cholesterol biosynthesis by SREBP (SREBF) PPARA activates gene expression Activation of gene expression by SREBF (SREBP) Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation EGR2 and SOX10-mediated initiation of Schwann cell myelination	ABC-family proteins mediated transport Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Defective CFTR causes cystic fibrosis ER Quality Control Compartment (ERQC)
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Birth weight ( 31043758 27680694) General cognitive ability ( 29844566) Processed meat consumption ( 32066663) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (MOSTest) ( 32665545) Multiple sclerosis ( 31604244) Rheumatoid arthritis (ACPA-positive) ( 24532676)
Interacting Genes		50 interacting genes: ABLIM1 ABLIM2 ARHGEF1 ARRB1 ATF7IP ATXN1 AURKA CASP3 CASP8AP2 COPS5 CREB1 CREBBP EGR1 EP300 FHL2 FHL3 GOLGB1 HNF4A HSPA5 INSIG1 INSIG2 ITGB4 KLF13 KPNB1 LINC00839 LZTR1 MAPK1 MAPK3 MRPS6 MTNR1B NAE1 NFYA NFYC OS9 PIAS1 PIAS2 PIAS3 PSMD4 RAB11B SCAP SLC4A4 SMAD3 SP1 SPTBN1 SUMO1 TTC1 UBE2I ZDHHC17 ZMYM2 ZYX	19 interacting genes: ACVR1B CPNE6 CREB3 DCSTAMP DYSF EGLN1 EGLN3 EIF6 FOXM1 HIF1A HSP90B1 LINC00839 MEP1B RBX1 SMAD2 SNRPD2 SREBF2 TRPV4 ZNF512B
Entrez ID		6721	10956
HPRD ID		02726	17804
Ensembl ID		ENSG00000198911	ENSG00000135506
Uniprot IDs		A0A024R1Q0 Q12772	Q13438
PDB IDs		1UKL	3AIH
Enriched GO Terms of Interacting Partners?
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