SREBF2 and HNF4A

Data Source:
HPRD (in vivo, in vitro)

		SREBF2	HNF4A
Description		sterol regulatory element binding transcription factor 2	hepatocyte nuclear factor 4 alpha
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GO Annotations	Cellular Component	Golgi Membrane Chromatin Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane SREBP-SCAP-Insig Complex Intracellular Membrane-bounded Organelle	Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	C-8 Sterol Isomerase Activity RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Protein C-terminus Binding Protein Dimerization Activity E-box Binding Sequence-specific Double-stranded DNA Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Signaling Receptor Binding Fatty Acid Binding Protein Binding Zinc Ion Binding Protein Homodimerization Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process Cholesterol Metabolic Process Regulation Of Notch Signaling Pathway Cellular Response To Starvation Positive Regulation Of Cholesterol Storage SREBP Signaling Pathway Cholesterol Homeostasis Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Low-density Lipoprotein Particle Stimulus Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Cholesterol Efflux Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Protein Targeting To Mitochondrion	Type B Pancreatic Cell Development Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Ornithine Metabolic Process Lipid Metabolic Process Xenobiotic Metabolic Process Sex Differentiation Blood Coagulation Negative Regulation Of Cell Population Proliferation Response To Glucose Regulation Of Gastrulation Regulation Of Lipid Metabolic Process Signal Transduction Involved In Regulation Of Gene Expression Cell Differentiation Negative Regulation Of Cell Growth Intracellular Receptor Signaling Pathway Glucose Homeostasis Cholesterol Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Anatomical Structure Development Regulation Of Insulin Secretion Lipid Homeostasis Phospholipid Homeostasis SMAD Protein Signal Transduction Triglyceride Homeostasis Hepatocyte Differentiation
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) Regulation of cholesterol biosynthesis by SREBP (SREBF) PPARA activates gene expression Activation of gene expression by SREBF (SREBP) Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation EGR2 and SOX10-mediated initiation of Schwann cell myelination	Nuclear Receptor transcription pathway
Drugs			Lauric acid AVI-4557 Myristic acid
Diseases			Maturity onset diabetes of the young (MODY)
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Birth weight ( 31043758 27680694) General cognitive ability ( 29844566) Processed meat consumption ( 32066663) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)	Apolipoprotein A1 levels ( 32203549) Apolipoprotein B levels ( 32203549) C-reactive protein ( 22939635) C-reactive protein levels ( 30388399 21300955) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 24097068 20686565) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coenzyme Q10 levels ( 27149984) Estimated glomerular filtration rate ( 31152163) Factor VII activity ( 30642921) Fibrinogen levels ( 28107422 26561523) Gallstone disease ( 30504769) Granulocyte count ( 27863252) HDL cholesterol ( 24097068 19060906 30275531 25961943 20686565) HDL cholesterol levels ( 32203549 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Hematocrit ( 32888494 27863252) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) LDL cholesterol levels ( 32203549) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Low density lipoprotein cholesterol levels ( 32154731) Lymphocyte percentage of white cells ( 32888494) Medication use (drugs used in diabetes) ( 31015401) Metabolic syndrome ( 31589552) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494 27863252) Pancreatic cancer ( 29422604) Red blood cell count ( 32888494) Serum uric acid levels ( 30993211) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Type 2 diabetes ( 24509480 30054458 21874001 30297969 29632382 31118516 32499647 22158537 30718926 28869590) Type 2 diabetes (adjusted for BMI) ( 29632382) Ulcerative colitis ( 19915572 23128233) Urate levels ( 31578528) White blood cell count ( 32888494)
Interacting Genes		50 interacting genes: ABLIM1 ABLIM2 ARHGEF1 ARRB1 ATF7IP ATXN1 AURKA CASP3 CASP8AP2 COPS5 CREB1 CREBBP EGR1 EP300 FHL2 FHL3 GOLGB1 HNF4A HSPA5 INSIG1 INSIG2 ITGB4 KLF13 KPNB1 LINC00839 LZTR1 MAPK1 MAPK3 MRPS6 MTNR1B NAE1 NFYA NFYC OS9 PIAS1 PIAS2 PIAS3 PSMD4 RAB11B SCAP SLC4A4 SMAD3 SP1 SPTBN1 SUMO1 TTC1 UBE2I ZDHHC17 ZMYM2 ZYX	69 interacting genes: ANP32B ARNT COPS5 CREBBP DDX3X DMD EIF1AY ESR1 FOXO1 GTF2B GTF2H1 HDAC3 HDAC4 HIF1A HNF1A ISL1 MAPK1 MAPK14 MAPK3 MECR MED1 MED10 MED14 MED16 MED17 MED21 MED24 MED7 NCOA1 NCOA2 NCOA6 NCOR2 NPPA NR0B2 NR1I2 NR1I3 NR2C2 NR2F1 NRBF2 NRIP1 PCBD1 PIAS4 PLPP2 PNRC1 PNRC2 PPARGC1A PPARGC1B PRKAA2 PRKACA PRMT1 PROX1 RNF4 SIRT1 SMAD2 SMAD3 SMAD4 SP1 SREBF1 SREBF2 SUB1 TAF6 TAF9 TBP TGS1 TP53 TRIM24 UBE2I XPO1 ZNHIT3
Entrez ID		6721	3172
HPRD ID		02726	02612
Ensembl ID		ENSG00000198911	ENSG00000101076
Uniprot IDs		A0A024R1Q0 Q12772	A0A087WXV4 B9VVT8 F1D8S2 F1D8T0 F1D8T1 P41235
PDB IDs		1UKL	1PZL 3CBB 3FS1 4B7W 4IQR 6CHT
Enriched GO Terms of Interacting Partners?
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